Benzaldehyde and azaphilone derivatives from the marine-derived fungus Penicillium sclerotiorum PSU-AMF89

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED Natural Product Research Pub Date : 2026-04-03 Epub Date: 2024-12-12 DOI:10.1080/14786419.2024.2442101

Praphatsorn Saetang , Vatcharin Rukachaisirikul , Saowanit Saithong , Souwalak Phongpaichit , Sita Preedanon , Jariya Sakayaroj

{"title":"Benzaldehyde and azaphilone derivatives from the marine-derived fungus Penicillium sclerotiorum PSU-AMF89","authors":"Praphatsorn Saetang , Vatcharin Rukachaisirikul , Saowanit Saithong , Souwalak Phongpaichit , Sita Preedanon , Jariya Sakayaroj","doi":"10.1080/14786419.2024.2442101","DOIUrl":null,"url":null,"abstract":"<div><div>Two new compounds including one benzaldehyde (1) and one azaphilone (2) were isolated from the marine-derived fungus Penicillium sclerotiorum PSU-AMF89 together with nine known compounds (3–11). Their structures were determined by spectroscopic evidences. The absolute configuration of 2 was established by comparison of the ECD data with those of the previously reported data of compound 7 as well as the biosynthetic consideration. Compound 1 displayed potent cytotoxic activity against MCF-7 cells with an IC50 value of 9 µM, compared with the standard drugs, tamoxifen and doxorubicin, whereas compounds 3 and 8 were moderately active against Cryptococcus neoformans and methicillin-resistant Staphylococcus aureus, respectively, with equal MIC values of 64 µg/mL. In addition, they were non-cytotoxic to noncancerous Vero cells.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 7","pages":"Pages 1905-1912"},"PeriodicalIF":1.6000,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1478641924009963","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/12 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}

引用次数: 0

Abstract

Two new compounds including one benzaldehyde (1) and one azaphilone (2) were isolated from the marine-derived fungus Penicillium sclerotiorum PSU-AMF89 together with nine known compounds (3–11). Their structures were determined by spectroscopic evidences. The absolute configuration of 2 was established by comparison of the ECD data with those of the previously reported data of compound 7 as well as the biosynthetic consideration. Compound 1 displayed potent cytotoxic activity against MCF-7 cells with an IC₅₀ value of 9 µM, compared with the standard drugs, tamoxifen and doxorubicin, whereas compounds 3 and 8 were moderately active against Cryptococcus neoformans and methicillin-resistant Staphylococcus aureus, respectively, with equal MIC values of 64 µg/mL. In addition, they were non-cytotoxic to noncancerous Vero cells.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

海洋真菌菌核青霉PSU-AMF89的苯甲醛和氮唑酮衍生物。

从海洋真菌菌核青霉PSU-AMF89中分离得到两个新化合物，包括一个苯甲醛(1)和一个氮唑酮(2)，以及9个已知化合物（3-11）。它们的结构由光谱证据确定。通过与先前报道的化合物7的ECD数据比较以及生物合成考虑，确定了化合物2的绝对构型。与标准药物他莫昔芬和阿霉素相比，化合物1对MCF-7细胞具有较强的细胞毒活性，IC50值为9µM，而化合物3和8对新型隐球菌和耐甲氧西林金黄色葡萄球菌分别具有中等活性，MIC值为64µg/mL。此外，它们对非癌性Vero细胞无细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.