Indole derivatives and their associated microbial genera are associated with the 1-year changes in cardiometabolic risk markers in Chinese adults.

IF 4.4 2区医学 Q1 NUTRITION & DIETETICS Nutrition Journal Pub Date : 2024-12-28 DOI:10.1186/s12937-024-01067-4

Yutong Pan, Yamin Li, Zhaohong Peng, Xiaoyu Zhang, Shu Ye, Na Chen, Zhuang Zhang, Wanshui Yang

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引用次数: 0

Abstract

Background: Although emerging evidence suggests that indole derivatives, microbial metabolites of tryptophan, may improve cardiometabolic health, the effective metabolites remain unclear. Also, the gut microbiota that involved in producing indole derivatives are less studied. We identified microbial taxa that can predict serum concentrations of the key indole metabolite indole-3-propionic acid (IPA) at population level and investigated the associations of indole derivatives and IPA-predicting microbial genera with cardiometabolic risk markers.

Methods: In a cohort of 318 community-dwelling adults, serum indole metabolites and fecal microbiota (16S ribosomal RNA) were measured at baseline. Total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and fasting blood glucose were repeatedly measured at baseline and again after 1 year. Brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI) were measured after 1 year. The association between indole derivatives and the 1-year changes in blood lipids and glucose, and association of indole derivatives with baPWV and ABI were investigated using linear regression models.

Results: Each 1 µmol/L increase in indole-3-acetic acid (IAA) levels was associated with 5.08% (P = 0.046) decrease in LDL-C. IPA levels were inversely associated with baPWV (percentage difference = -1.32%, P = 0.036). Per 1 µmol/L increase in Indole-3-aldehyde (IAld) levels was associated with 1.91% (P = 0.004) decrease in TC and 0.58% (P = 0.019) increase in ABI, but 1.79% decrease in HDL-C with borderline significance (P = 0.050). We identified 18 bacterial genera whose relative abundance was positively associated with serum IPA concentrations (P_FDR < 0.05) and constructed a microbial score to reflect the overall IPA-producing potential. This score was inversely associated with baPWV (percentage difference = -0.48%, P = 0.007).

Conclusions: Our results suggest that IAA, IPA, IAld, and IPA-predicting microbial score are favorably associated with several cardiometabolic risk markers, although IAld may decrease HDL-C levels.

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吲哚衍生物及其相关微生物属与中国成年人心脏代谢风险标志物的1年变化有关。

背景：尽管越来越多的证据表明吲哚衍生物，色氨酸的微生物代谢产物，可能改善心脏代谢健康，但有效的代谢产物仍不清楚。此外，参与产生吲哚衍生物的肠道微生物群也很少被研究。我们确定了能够在人群水平上预测吲哚关键代谢物吲哚-3-丙酸（IPA）血清浓度的微生物类群，并研究了吲哚衍生物和IPA预测微生物属与心脏代谢危险标志物的关系。方法：在318名社区居民的队列中，基线时测定血清吲哚代谢物和粪便微生物群（16S核糖体RNA）。在基线和1年后重复测量总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和空腹血糖。1年后测量肱-踝脉搏波速度（baPWV）和踝-肱指数（ABI）。采用线性回归模型研究吲哚衍生物与1年血脂和血糖变化的关系，以及吲哚衍生物与baPWV和ABI的关系。结果：吲哚-3-乙酸（IAA）水平每升高1µmol/L， LDL-C降低5.08% （P = 0.046）。IPA水平与baPWV呈负相关（百分比差异= -1.32%,P = 0.036）。吲哚-3醛（IAld）水平每升高1µmol/L， TC降低1.91% (P = 0.004)， ABI升高0.58% (P = 0.019)， HDL-C降低1.79% （P = 0.050）。我们鉴定出18个细菌属，它们的相对丰度与血清IPA浓度呈正相关（PFDR < 0.05），并构建了一个微生物评分来反映整体IPA的产生潜力。该评分与baPWV呈负相关（百分比差异= -0.48%,P = 0.007）。结论：我们的研究结果表明，IAA、IPA、IAld和IPA预测微生物评分与几种心脏代谢风险标志物有利相关，尽管IAld可能降低HDL-C水平。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.