{"title":"Recent advances and FDA approvals in nanoformulations for drug delivery","authors":"Anahita Asadi, Onyinyechi Obidiro, Rashidat Elesho, Kafilat Agbaje, Mohammadali Kochakzade, Pradeep Kumar Karla","doi":"10.1007/s11051-024-06199-6","DOIUrl":null,"url":null,"abstract":"<div><p>The use of nanotechnology to make nanoformulations/nanocarriers is a rapidly evolving field of study with the potential to fundamentally improve the treatment outcomes for diverse disease states. The use of nanoformulations allows for targeted drug delivery to diseased sites and reduced unwanted side effects. There have been many FDA-approved nanoformulations for the treatment of complex disease states such as advanced non‐small cell lung cancer, secondary metastatic breast cancer, primary metastatic pancreatic cancer, Kaposi’s sarcoma related to AIDS, ovarian cancer, multiple myeloma, leukemia, amyloidosis, and age-related macular degeneration. While most nanoformulations are approved for cancer therapy, FDA-approved nanoformulations are effectively employed to treat autoimmune disorders, metabolic disorders, ophthalmic conditions, neurological diseases, hematological disorders, and inflammatory diseases. Further, novel nanoformulations are in various phases of clinical development for endocrine disorders, complex cancers, skin, ocular, blood, nervous system, cardiovascular, immune, and inflammatory disorders.</p></div>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"27 1","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nanoparticle Research","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s11051-024-06199-6","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The use of nanotechnology to make nanoformulations/nanocarriers is a rapidly evolving field of study with the potential to fundamentally improve the treatment outcomes for diverse disease states. The use of nanoformulations allows for targeted drug delivery to diseased sites and reduced unwanted side effects. There have been many FDA-approved nanoformulations for the treatment of complex disease states such as advanced non‐small cell lung cancer, secondary metastatic breast cancer, primary metastatic pancreatic cancer, Kaposi’s sarcoma related to AIDS, ovarian cancer, multiple myeloma, leukemia, amyloidosis, and age-related macular degeneration. While most nanoformulations are approved for cancer therapy, FDA-approved nanoformulations are effectively employed to treat autoimmune disorders, metabolic disorders, ophthalmic conditions, neurological diseases, hematological disorders, and inflammatory diseases. Further, novel nanoformulations are in various phases of clinical development for endocrine disorders, complex cancers, skin, ocular, blood, nervous system, cardiovascular, immune, and inflammatory disorders.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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