The comparative effects of ω-7 fatty acid-rich sea buckthorn oil and ω-3 fatty acid-rich DHA algal oil on improving high-fat diet-induced hyperlipidemia†

Abstract

This study explores the therapeutic potential of ω-3 algal oil (rich in DHA) and ω-7 sea buckthorn oil (rich in palmitoleic acid) in addressing hyperlipidemia and associated metabolic disorders. These oils regulate lipid metabolism through the PPARγ-LXRα-ABCA1/ABCG1 signaling pathway, reducing cholesterol accumulation, oxidative stress, and inflammation. In high-fat diet-induced hyperlipidemic mice, supplementation with these oils significantly improved lipid profiles, alleviated hepatic steatosis, and promoted cardiovascular health. The combination of ω-3 and ω-7 fatty acids showed synergistic effects, offering greater efficacy compared to individual treatments. These findings suggest that algal and sea buckthorn oils could serve as dietary supplements or therapeutic interventions for managing hyperlipidemia, non-alcoholic fatty liver disease (NAFLD), and cardiovascular diseases. This study highlights the potential of these oils as novel, natural solutions for metabolic health improvement.