Assessment of social isolation and changes in Parkinson's disease symptoms during the COVID-19 pandemic: A longitudinal study.

IF 1.9 Q3 CLINICAL NEUROLOGY Clinical Parkinsonism Related Disorders Pub Date : 2024-12-09 eCollection Date: 2025-01-01 DOI:10.1016/j.prdoa.2024.100293

Anish Mehta, Samuel Y E Ng, Shermyn X M Neo, Nicole S Y Chia, Ehsan S Saffari, Thyagarajan Shivashanmugam, Xinyi Choi, Dede L Heng, Z Y Xu, K Y Tay, W L Au, E K Tan, Louis C S Tan

{"title":"Assessment of social isolation and changes in Parkinson's disease symptoms during the COVID-19 pandemic: A longitudinal study.","authors":"Anish Mehta, Samuel Y E Ng, Shermyn X M Neo, Nicole S Y Chia, Ehsan S Saffari, Thyagarajan Shivashanmugam, Xinyi Choi, Dede L Heng, Z Y Xu, K Y Tay, W L Au, E K Tan, Louis C S Tan","doi":"10.1016/j.prdoa.2024.100293","DOIUrl":null,"url":null,"abstract":"Background: COVID-19-related social restrictions provided an opportunity to evaluate the impact of social isolation on Parkinson's disease.Objective: This study aimed to explore changes in social isolation and their associations with PD symptoms using the Lubben Social Network Scale-Revised (LSNS-R).Methods: Data from 80 participants of the Early Parkinson's Disease Longitudinal Singapore cohort were collected from April 2019 to April 2023, covering the periods before and after the imposition of COVID-19 restrictions. Individuals with LSNS-R scores ≤ 24 were considered socially isolated. Data were stratified into strata 1 (improved LSNS-R scores) and strata 2 (worsened/unchanged scores). Linear regression was used to identify predictors of LSNS-R change, and MANCOVA was used to examine associations between LSNS-R change and motor/ non-motor symptoms.Results: Mean LSNS-R scores decreased (p = 0.014), and proportions of social isolation increased (p < 0. 001) during COVID-19 restrictions. However, 35 % showed improved LSNS-R scores, while 65 % had worsened/unchanged scores. The regression model was significant in strata 1 (R2 = 0.806, p = 0.001), with age, marital status, and social isolation status being significantly associated with change in LSNS-R scores. LSNS-R. Results of MANCOVA indicated that LSNS-R improvements in LSNS-R were significantly associated with outcomes (Roy's Largest Root statistic = 126.638, p < 0.001), particularly for changes in PDQ8, HADS-Anxiety, and HADS-Depression scores. The regression model was not significant in strata 2 (R2 = 0. 279, p = 0.206), wherein motor and non-motor symptoms worsened.Conclusion: While worsening LSNS-R scores were associated with poorer outcomes, improvements in social networks were associated with improved non-motor symptoms and quality of life. These findings underscore the complexity of social isolation in PD and the need for targeted interventions.","PeriodicalId":33691,"journal":{"name":"Clinical Parkinsonism Related Disorders","volume":"12 ","pages":"100293"},"PeriodicalIF":1.9000,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11696853/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Parkinsonism Related Disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.prdoa.2024.100293","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: COVID-19-related social restrictions provided an opportunity to evaluate the impact of social isolation on Parkinson's disease.

Objective: This study aimed to explore changes in social isolation and their associations with PD symptoms using the Lubben Social Network Scale-Revised (LSNS-R).

Methods: Data from 80 participants of the Early Parkinson's Disease Longitudinal Singapore cohort were collected from April 2019 to April 2023, covering the periods before and after the imposition of COVID-19 restrictions. Individuals with LSNS-R scores ≤ 24 were considered socially isolated. Data were stratified into strata 1 (improved LSNS-R scores) and strata 2 (worsened/unchanged scores). Linear regression was used to identify predictors of LSNS-R change, and MANCOVA was used to examine associations between LSNS-R change and motor/ non-motor symptoms.

Results: Mean LSNS-R scores decreased (p = 0.014), and proportions of social isolation increased (p < 0. 001) during COVID-19 restrictions. However, 35 % showed improved LSNS-R scores, while 65 % had worsened/unchanged scores. The regression model was significant in strata 1 (R2 = 0.806, p = 0.001), with age, marital status, and social isolation status being significantly associated with change in LSNS-R scores. LSNS-R. Results of MANCOVA indicated that LSNS-R improvements in LSNS-R were significantly associated with outcomes (Roy's Largest Root statistic = 126.638, p < 0.001), particularly for changes in PDQ8, HADS-Anxiety, and HADS-Depression scores. The regression model was not significant in strata 2 (R2 = 0. 279, p = 0.206), wherein motor and non-motor symptoms worsened.

Conclusion: While worsening LSNS-R scores were associated with poorer outcomes, improvements in social networks were associated with improved non-motor symptoms and quality of life. These findings underscore the complexity of social isolation in PD and the need for targeted interventions.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

COVID-19大流行期间社会隔离和帕金森病症状变化的评估：一项纵向研究

背景：与covid -19相关的社会限制为评估社会隔离对帕金森病的影响提供了机会。目的：本研究旨在利用Lubben社会网络量表（LSNS-R）探讨社会隔离的变化及其与PD症状的关系。方法：从2019年4月至2023年4月收集了80名早期帕金森病新加坡纵向队列参与者的数据，涵盖了COVID-19限制实施前后的时期。LSNS-R评分≤24的个体被认为是社会孤立的。将数据分为第1层（改善的LSNS-R评分）和第2层（恶化/不变的评分）。使用线性回归来确定LSNS-R变化的预测因子，并使用MANCOVA来检查LSNS-R变化与运动/非运动症状之间的关联。结果：平均LSNS-R评分下降（p = 0.014），社会隔离比例增加(p)。结论：LSNS-R评分恶化与预后较差相关，而社会网络的改善与非运动症状和生活质量的改善相关。这些发现强调了PD中社会隔离的复杂性和有针对性干预的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊