Novel water-soluble gelatin-based platinum nanoparticles for targeted cancer therapy with enhanced cytotoxicity

IF 2.1 4区材料科学 Q3 CHEMISTRY, MULTIDISCIPLINARY Journal of Nanoparticle Research Pub Date : 2025-01-06 DOI:10.1007/s11051-024-06212-y

Ebru Deniz Ünal, Enes Duymaz, Serdar Batıkan Kavukcu, Senthil Rethinam, Gülşah Türkmen, Bahri Başaran, Hayati Türkmen

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Abstract

The development of effective and targeted cancer therapies remains a significant challenge. Platinum-based drugs are widely used but often suffer from limitations such as systemic toxicity and resistance. This study presents a novel approach to address these limitations by developing water-soluble gelatin-based platinum nanoparticles (PtNPs) for enhanced cancer therapy. The incorporation of gelatin and curcumin into these nanoparticles offers potential advantages in terms of biocompatibility, targeted delivery, and synergistic therapeutic effects. The PtNPs were conveniently synthesized using a nanosuspension technique, offering a potentially scalable and straightforward method for nanoparticle production. The synthesized PtNPs were thoroughly characterized using various techniques. The investigation assessed the cytotoxic properties of the PtNPs in MCF-7 (breast cancer) and HepG2 (liver cancer) cell lines. The average size of PtNPs was found to vary around 120–200 nm. The density of platinum metal was supported by EDS and metal mapping analysis. The IC₅₀ values of PtNPs in MCF-7 and HepG2 cancer cell lines were found to be 6.450 and 7.992 μL/mL, respectively. The incorporation of gelatin and curcumin into platinum nanoparticles represents a unique and innovative strategy for enhancing nanoparticle biocompatibility, targeting, and therapeutic efficacy.

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新型水溶性明胶基铂纳米颗粒靶向癌症治疗与增强细胞毒性

开发有效的靶向癌症疗法仍然是一个重大挑战。铂类药物被广泛使用，但往往受到全身毒性和耐药性等限制。本研究提出了一种新的方法，通过开发水溶性明胶基铂纳米颗粒（PtNPs）来增强癌症治疗，从而解决这些限制。将明胶和姜黄素掺入这些纳米颗粒在生物相容性、靶向递送和协同治疗效果方面具有潜在的优势。利用纳米悬浮液技术方便地合成了PtNPs，为纳米颗粒的生产提供了一种潜在的可扩展和直接的方法。利用各种技术对合成的PtNPs进行了全面表征。该研究评估了PtNPs在MCF-7（乳腺癌）和HepG2（肝癌）细胞系中的细胞毒性。PtNPs的平均尺寸在120-200 nm之间。能谱分析和金属图分析证实了铂金属的密度。MCF-7和HepG2癌细胞中PtNPs的IC50值分别为6.450和7.992 μL/mL。将明胶和姜黄素结合到铂纳米颗粒中代表了一种独特的创新策略，可以增强纳米颗粒的生物相容性、靶向性和治疗效果。

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来源期刊

Journal of Nanoparticle Research 工程技术-材料科学：综合

CiteScore

4.40

自引率

4.00%

发文量

198

审稿时长

3.9 months

期刊介绍： The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size. Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology. The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.