Do patients with early-stage cognitive impairment have an increased risk to have a reduction in walking speed? A cross-sectional study

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2025-01-09 DOI:10.1002/alz.089259

Pedro de Castro Lopes, Amanda Aparecida Oliveira Leopoldino, João Carlos Barbosa Machado, Maira Tonidandel Barbosa, Luana Rodrigues Garcia, Bianca Pessoa Aguiar, Júlia Caroline Barbosa de Souza, João Pedro Neres Antunes Ferreira

{"title":"Do patients with early-stage cognitive impairment have an increased risk to have a reduction in walking speed? A cross-sectional study","authors":"Pedro de Castro Lopes, Amanda Aparecida Oliveira Leopoldino, João Carlos Barbosa Machado, Maira Tonidandel Barbosa, Luana Rodrigues Garcia, Bianca Pessoa Aguiar, Júlia Caroline Barbosa de Souza, João Pedro Neres Antunes Ferreira","doi":"10.1002/alz.089259","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Gait speed is an important measure in the evaluation of elderly patients. The gait speed reduction is associated with high-impact outcomes such as: loss of functionality, frailty and increased mortality. Several clinical conditions lead to a reduction in gait speed. In patients with advanced dementia, it could be associated with disability. However, the relationship between cognition and motor function is not well known, especially in the early stages of dementia and further studies are needed. It is also important to understand whether patients with mild cognitive impairment have increased risk of a worse gait speed.</p>\n </section>\n \n <section>\n \n <h3> Method</h3>\n \n <p>This is a cross-sectional study in which 87 community-dwelling elderly people were included and evaluated in relation to the presence of cognitive impairment and gait speed. Patients with severe cognitive impairment, assessed by a score less than 6 in the CS-10 (Point Cognitive Screening) were excluded. Individuals with a score between 6 and 7 on the CS-10 were considered to have mild or moderate cognitive impairment and participants with a score greater than 7 on this test were considered to have no cognitive impairment. In order to evaluate gait speed, individuals were stimulated to walk for 4 meters, and those with a walking speed lower than 0.82 m/s were considered to have it reduced. With the aim of estimate the association between the characteristics, Pearson’s chi-square test was used. If the p-value was lower than the significance level of 0.05, it is possible to conclude the association between the lower walking speed and a worse score in CS-10.</p>\n </section>\n \n <section>\n \n <h3> Result</h3>\n \n <p>Statistical analysis showed an association between the reduction in gait speed and CS-10 score (p-value 0.041). Patients who had lower score on the cognitive assessment are likely to have a lower gait speed. The mean CS-10 score for patients with gait impairment is 7.91, while for patients without gait impairment is 8.95 points. The Kruskal-Wallis test indicates that there is a significant difference in the results (p-value 0.016).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Individuals with mild cognitive impairment have an increased risk of developing reduced gait speed.</p>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"20 S7","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.089259","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.089259","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Gait speed is an important measure in the evaluation of elderly patients. The gait speed reduction is associated with high-impact outcomes such as: loss of functionality, frailty and increased mortality. Several clinical conditions lead to a reduction in gait speed. In patients with advanced dementia, it could be associated with disability. However, the relationship between cognition and motor function is not well known, especially in the early stages of dementia and further studies are needed. It is also important to understand whether patients with mild cognitive impairment have increased risk of a worse gait speed.

Method

This is a cross-sectional study in which 87 community-dwelling elderly people were included and evaluated in relation to the presence of cognitive impairment and gait speed. Patients with severe cognitive impairment, assessed by a score less than 6 in the CS-10 (Point Cognitive Screening) were excluded. Individuals with a score between 6 and 7 on the CS-10 were considered to have mild or moderate cognitive impairment and participants with a score greater than 7 on this test were considered to have no cognitive impairment. In order to evaluate gait speed, individuals were stimulated to walk for 4 meters, and those with a walking speed lower than 0.82 m/s were considered to have it reduced. With the aim of estimate the association between the characteristics, Pearson’s chi-square test was used. If the p-value was lower than the significance level of 0.05, it is possible to conclude the association between the lower walking speed and a worse score in CS-10.

Result

Statistical analysis showed an association between the reduction in gait speed and CS-10 score (p-value 0.041). Patients who had lower score on the cognitive assessment are likely to have a lower gait speed. The mean CS-10 score for patients with gait impairment is 7.91, while for patients without gait impairment is 8.95 points. The Kruskal-Wallis test indicates that there is a significant difference in the results (p-value 0.016).

Conclusion

Individuals with mild cognitive impairment have an increased risk of developing reduced gait speed.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

早期认知障碍患者行走速度降低的风险是否增加？横断面研究

步态速度是评价老年患者的重要指标。步态速度降低与高影响结果相关，如：功能丧失、虚弱和死亡率增加。几种临床情况会导致步态速度减慢。在晚期痴呆患者中，它可能与残疾有关。然而，认知和运动功能之间的关系尚不清楚，特别是在痴呆症的早期阶段，需要进一步的研究。同样重要的是要了解轻度认知障碍患者是否会增加步速恶化的风险。方法这是一项横断面研究，纳入了87名社区居住的老年人，并评估了认知障碍和步态速度的存在。CS - 10评分低于6分的严重认知障碍患者被排除在外。CS - 10得分在6到7分之间的个体被认为有轻度或中度认知障碍，得分大于7分的参与者被认为没有认知障碍。为了评估步态速度，我们刺激个体步行4米，当步行速度低于0.82 m/s时，我们认为行走速度降低了。为了估计这些特征之间的相关性，我们使用了皮尔逊卡方检验。如果p值低于0.05的显著性水平，则可以得出较低的步行速度与较差的CS - 10评分之间的关联。结果统计分析显示，步态速度的降低与CS - 10评分之间存在相关性（p值为0.041）。在认知评估中得分较低的患者可能有较低的步态速度。步态障碍患者的CS‐10平均评分为7.91分，而无步态障碍患者的CS‐10平均评分为8.95分。Kruskal - Wallis检验表明结果有显著差异（p值为0.016）。结论轻度认知障碍患者步态速度减慢的风险增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.