Late-stage C–H trifluoroacetylation of quinoxaline-2(1H)-ones using masked trifluoroacyl reagents†

IF 2.7 3区 化学 Q1 CHEMISTRY, ORGANIC Organic & Biomolecular Chemistry Pub Date : 2024-12-30 DOI:10.1039/d4ob01945h
Yawei Shen , Yuan Li , Xia Wang , Jiaoyan Wei , Yafen Shen , Lei Wu , Kai Luo
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Abstract

A strategy for trifluoroacetylation of quinoxaline-2(1H)-ones has been investigated. This strategy employs masked trifluoroacyl reagents to obtain trifluoroacetylated quinoxaline-2(1H)-ones under metal-, catalyst-, and light-free conditions. This approach is distinguished by its functional group compatibility and tolerance, as well as the simplicity of the experimental process, making it suitable for gram-scale synthesis.

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用掩膜三氟酰基试剂对喹诺啉-2(1H)- 1进行后期C-H三氟乙酰化。
研究了喹诺啉-2(1H)- 1的三氟乙酰化策略。该策略采用屏蔽三氟酰基试剂,在金属、催化剂和无光条件下获得三氟乙酰化喹诺啉-2(1H)-试剂。该方法的特点是其官能团相容性和耐受性,以及实验过程的简单性,使其适合克级合成。
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来源期刊
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry 化学-有机化学
CiteScore
5.50
自引率
9.40%
发文量
1056
审稿时长
1.3 months
期刊介绍: Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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