{"title":"Recent breakthroughs in ring-opening annulation reactions of aziridines.","authors":"Deepak Ranjan Mishra, Nilima Priyadarsini Mishra","doi":"10.1039/d4ob01577k","DOIUrl":null,"url":null,"abstract":"<p><p>Aziridines, characterized by their highly constrained three-membered nitrogen-containing heterocyclic ring system, serve as compelling synthetic intermediates for synthesizing numerous naturally occurring alkaloids and pharmaceuticals. The distinct ring strain arising from the geometric constraints of these sp<sup>3</sup>-rich trigonal rings imparts high reactivity, thereby offering a wealth of intriguing synthetic opportunities. Recent advances in the chemistry and reactivity of aziridines have unveiled significant progress in preparing more complex heterocycles. This review consolidates and examines recent publications on the ring-opening annulation reactions of aziridines, highlighting the latest breakthroughs, emerging trends, and future directions in this dynamic field.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4ob01577k","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Aziridines, characterized by their highly constrained three-membered nitrogen-containing heterocyclic ring system, serve as compelling synthetic intermediates for synthesizing numerous naturally occurring alkaloids and pharmaceuticals. The distinct ring strain arising from the geometric constraints of these sp3-rich trigonal rings imparts high reactivity, thereby offering a wealth of intriguing synthetic opportunities. Recent advances in the chemistry and reactivity of aziridines have unveiled significant progress in preparing more complex heterocycles. This review consolidates and examines recent publications on the ring-opening annulation reactions of aziridines, highlighting the latest breakthroughs, emerging trends, and future directions in this dynamic field.
期刊介绍：
Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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