Modified Taohong Siwu Decoction Improved Cardiac Function after Myocardial Infarction by Activating PI3K/Akt Signaling Pathway.

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY Current pharmaceutical design Pub Date : 2025-01-07 DOI:10.2174/0113816128341178241028062518

Han Li, Zhi-Rong Luo, Meng-Ying Huang, Hao Cai, Ping-Ping Lu, Yan-Wu Xu, Ming-Jie Li, Hai-Dong Guo

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Abstract

Introduction: Taohong Siwu decoction (THSWD), a traditional prescription for enhancing blood circulation and eliminating blood stasis, primarily comprises peach kernel, safflower, angelica, chuanxiong, and rehmannia. Modified Taohong Siwu decoction (MTHSWD), an advanced version of THSWD, incorporates additional ingredients such as epimedium, cinnamon, and salvia miltiorrhiza. This addition serves to augment its efficacy in warming yang and promoting blood circulation. MTHSWD has excellent heart protection in cardiac damage, which indicates a promising application prospect. However, the mechanisms are yet unclear.

Methods: In this study, network pharmacology and molecular docking studies demonstrated that the effects of MTHSWD may be significantly influenced by the PI3K/Akt signaling pathway. In addition, to verify this mechanism, three groups were divided and randomly selected from among the 35 Sprague-Dawley rats: Myocardial infarction (MI) group, THSWD group, and MTHSWD group.

Results: MTHSWD greatly improved fractional shortening as well as ejection fraction and reduced the infarct size. MTHSWD attenuated cell apoptosis by activating the Akt pathway in infarcted areas. In vitro, the cytoprotective effects of MTHSWD on H9C2 cells were significantly attenuated when PI3K/Akt was inhibited.

Conclusion: Therefore, the study found that MTHSWD had a positive effect on heart function after myocardial infarction by activating the Akt pathway.

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桃红四物汤通过激活PI3K/Akt信号通路改善心肌梗死后心功能。

简介：桃红四物汤是一种传统的活血化瘀方，主要成分包括桃仁、红花、当归、川芎和地黄。改良桃红四物汤（MTHSWD）是桃红四物汤的高级版本，加入了淫羊藿、肉桂和丹参等额外成分。这种添加物有助于增强其温阳和促进血液循环的功效。MTHSWD对心脏损伤具有良好的保护作用，具有广阔的应用前景。然而，其机制尚不清楚。方法：本研究通过网络药理学和分子对接研究表明，MTHSWD的作用可能受PI3K/Akt信号通路的显著影响。此外，为了验证这一机制，我们从35只Sprague-Dawley大鼠中随机抽取3组：心肌梗死（MI）组、THSWD组和MTHSWD组。结果：MTHSWD能明显改善梗死缩短分数和射血分数，缩小梗死面积。MTHSWD通过激活梗死区Akt通路减轻细胞凋亡。在体外实验中，当PI3K/Akt被抑制时，MTHSWD对H9C2细胞的细胞保护作用显著减弱。结论：本研究发现MTHSWD通过激活Akt通路对心肌梗死后心功能有积极作用。

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.