Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure

IF 15.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Nature Communications Pub Date : 2025-01-12 DOI:10.1038/s41467-025-55911-0

Tess E. Peterson, Virginia S. Hahn, Ruin Moaddel, Min Zhu, Sabina A. Haberlen, Frank J. Palella, Michael Plankey, Joel S. Bader, Joao A. C. Lima, Robert E. Gerszten, Jerome I. Rotter, Stephen S. Rich, Susan R. Heckbert, Gregory D. Kirk, Damani A. Piggott, Luigi Ferrucci, Joseph B. Margolick, Todd T. Brown, Katherine C. Wu, Wendy S. Post

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Abstract

People living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteomics concurrently with cardiac magnetic resonance imaging in two independent study populations to identify parallels between HIV-related and aging-related immune dysfunction that could contribute to atrial remodeling and clinical heart failure. We discover a plasma proteomic signature that may in part reflect or contribute to HIV-associated atrial remodeling, many features of which are associated with older age and time to incident heart failure among an independent community-based cohort without HIV. This proteomic profile was statistically enriched for immune checkpoint proteins, tumor necrosis factor signaling, ephrin signaling, and extracellular matrix organization, identifying possible shared pathways in HIV and aging that may contribute to risk of heart failure.

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hiv相关亚临床左心房重构和心力衰竭的蛋白质组学特征

与未感染艾滋病毒的人相比，艾滋病毒感染者患心力衰竭和相关左心房重构的风险更高。机制尚不清楚，但与炎症和早衰有关。在这里，我们在两个独立的研究人群中同时获得血浆蛋白质组学和心脏磁共振成像，以确定hiv相关和衰老相关的免疫功能障碍之间的相似之处，这些免疫功能障碍可能导致心房重构和临床心力衰竭。我们发现血浆蛋白质组学特征可能部分反映或促成HIV相关的心房重构，其中许多特征与年龄和发生心力衰竭的时间有关。免疫检查点蛋白、肿瘤坏死因子信号、ephrin信号和细胞外基质组织的蛋白质组学图谱在统计学上丰富，确定了HIV和衰老可能导致心力衰竭风险的共同途径。

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.