Design of new DOX coupling GQDs nanoparticles with enhanced optoelectronic features for drug delivery

IF 3.3 3区工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Optical and Quantum Electronics Pub Date : 2025-01-11 DOI:10.1007/s11082-024-06360-4

Kenza Elkabiri, Hala Ouarrad, Lalla Btissam Drissi

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Abstract

In this study, we present a novel drug-functionalized Graphene quantum dots (GQDs) as an effective system for drug delivery as well as imaging. The aforementioned GQDs are chosen in two different sizes in order to examine the effect of quantum confinement on our systems. As an effective drug for cancer treatment, Doxorubicine (DOX) is the studied element due to its organic nature. The optoelectronic and photoluminescence responses of different configurations of DOX bonding with GQDs are computationally investigated to assess their effectiveness in nanomedical fields to aimed target. The absence of negative frequencies reveals the stability of the new combined structures. Furthermore, H-L energy gap decreases with the increment of QDs size and mainly depends on Dox bonding on GQDs as well its the hardness of the nanoparticles. Consequently, the optical absorption and emission spectra undergo a red-shift after DOX coupling. In addition, GQDs+drug exhibit a strong photoluminescence in the Near-infrared region. This optical profile prompts the suitability of the coupled systems for drug delivery and nanomedical diagnostic applications.

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新型DOX耦合GQDs纳米颗粒的设计，具有增强的光电特性，用于给药

在这项研究中，我们提出了一种新的药物功能化石墨烯量子点（GQDs）作为药物传递和成像的有效系统。为了检验量子约束对系统的影响，我们选择了两种不同尺寸的GQDs。多柔比星（DOX）作为一种治疗癌症的有效药物，由于其有机性质而成为研究元素。计算研究了不同构型DOX与GQDs键合的光电和光致发光响应，以评估其在纳米医学领域对目标的有效性。负频率的缺失揭示了新组合结构的稳定性。H-L能隙随着量子点尺寸的增大而减小，主要取决于量子点上的Dox键和纳米粒子的硬度。因此，在DOX耦合后，光学吸收和发射光谱发生红移。此外，GQDs+药物在近红外区域表现出较强的光致发光。这种光学轮廓提示耦合系统的药物输送和纳米医学诊断应用的适用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Optical and Quantum Electronics 工程技术-工程：电子与电气

CiteScore

4.60

自引率

20.00%

发文量

810

审稿时长

3.8 months

期刊介绍： Optical and Quantum Electronics provides an international forum for the publication of original research papers, tutorial reviews and letters in such fields as optical physics, optical engineering and optoelectronics. Special issues are published on topics of current interest. Optical and Quantum Electronics is published monthly. It is concerned with the technology and physics of optical systems, components and devices, i.e., with topics such as: optical fibres; semiconductor lasers and LEDs; light detection and imaging devices; nanophotonics; photonic integration and optoelectronic integrated circuits; silicon photonics; displays; optical communications from devices to systems; materials for photonics (e.g. semiconductors, glasses, graphene); the physics and simulation of optical devices and systems; nanotechnologies in photonics (including engineered nano-structures such as photonic crystals, sub-wavelength photonic structures, metamaterials, and plasmonics); advanced quantum and optoelectronic applications (e.g. quantum computing, memory and communications, quantum sensing and quantum dots); photonic sensors and bio-sensors; Terahertz phenomena; non-linear optics and ultrafast phenomena; green photonics.