Characterization and Nutritional Intervention Effects of Canna edulis Type 5 Resistant Starch in Hyperlipidemia Mice.

IF 4.7 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY Foods Pub Date : 2025-01-02 DOI:10.3390/foods14010092

Houxier Li, Nan Wang, Jiahui Wu, Shuting Tan, Yan Li, Nan Zhang, Li Yang, Aji Li, Rongting Min, Maochun Xiao, Shiyao Su, Xiang Wang, Xueyong Wang

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Abstract

Numerous reports have indicated that the type 3 resistant starch (RS3) derived from Canna edulis can regulate lipid metabolism. However, it remains unclear whether the type 5 resistant starch (RS5) exhibits similar effects. In this study, RS5 was prepared from Canna edulis native starch and lauric acid through a hydrothermal method for the first time, and its nutritional intervention effects on hyperlipidemia in mice were investigated. The Canna edulis type 5 resistant starch (Ce-RS5) prepared using Canna edulis native starch and lauric acid exhibited a high compound index and resistant starch content, along with decreased swelling power and enhanced starch granule stability. The crystallinity of Ce-RS5 was decreased, and its crystal structure displayed a B+V pattern. Microscopically, the surface appeared rough with deepened grooves, and the granules were loose. Feeding mice with 1.5 g/kg and 3 g/kg of Ce-RS5 significantly reduced their body weight, positively regulated their blood lipid levels, and improved liver damage and fat accumulation. Additionally, Ce-RS5 promoted the abundance of beneficial gut bacteria, such as norank_f_Muribaculaceae, and inhibited the abundance of harmful bacteria like Colidextribacter. This study provides the first evidence of the hypolipidemic and weight loss effects of Ce-RS5 in hyperlipidemia mice.

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美人蕉5型抗性淀粉对高脂血症小鼠的特性及营养干预作用。

大量报道表明，美人蕉3型抗性淀粉（RS3）具有调节脂质代谢的作用。然而，目前尚不清楚5型抗性淀粉（RS5）是否表现出类似的效果。本研究首次以美人蕉原生淀粉和月桂酸为原料，通过水热法制备RS5，研究其对小鼠高脂血症的营养干预作用。以美人蕉原生淀粉和月桂酸为原料制备的美人蕉5型抗性淀粉（Ce-RS5）具有较高的复合指数和抗性淀粉含量，降低了膨胀性，提高了淀粉粒稳定性。Ce-RS5的结晶度降低，晶体结构呈B+V型。显微镜下，表面粗糙，沟槽加深，颗粒疏松。饲喂1.5 g/kg和3 g/kg Ce-RS5可显著降低小鼠体重，积极调节血脂水平，改善肝脏损伤和脂肪堆积。此外，Ce-RS5促进了norank_f_Muribaculaceae等有益肠道细菌的丰度，抑制了Colidextribacter等有害细菌的丰度。本研究首次证实了Ce-RS5对高脂血症小鼠的降血脂和减肥作用。

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来源期刊

Foods Immunology and Microbiology-Microbiology

CiteScore

7.40

自引率

15.40%

发文量

3516

审稿时长

15.83 days

期刊介绍： Foods (ISSN 2304-8158) is an international, peer-reviewed scientific open access journal which provides an advanced forum for studies related to all aspects of food research. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists, researchers, and other food professionals to publish their experimental and theoretical results in as much detail as possible or share their knowledge with as much readers unlimitedly as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. There are, in addition, unique features of this journal: manuscripts regarding research proposals and research ideas will be particularly welcomed electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material we also accept manuscripts communicating to a broader audience with regard to research projects financed with public funds