Multiparametric functional MRI of the kidneys - evaluation of test-retest repeatability and effects of different manual and automatic image analysis strategies.

Abstract

Multiparametric MRI is a promising technique for noninvasive structural and functional imaging of the kidneys that is gaining increasing importance in clinical research. Still, there are no standardized recommendations for analyzing the acquired images and there is a need to further evaluate the accuracy and repeatability of currently recommended MRI parameters. The aim of the study was to evaluate the test-retest repeatability of functional renal MRI parameters using different image analysis strategies.Ten healthy volunteers were examined twice with a multiparametric renal MRI protocol including arterial spin labeling (ASL), diffusion-weighted imaging (DWI) with intravoxel incoherent motion (IVIM), blood-oxygen-dependent (BOLD) imaging, T1 and T2 mapping, and volumetry with an interval of one week. The quantitative results of both kidneys were determined by manual organ segmentation, ROI analysis, and automatic segmentation based on the nnUNet framework. Test-retest repeatability of each parameter was computed using the within-subject coefficient of variance (wCV) and the intraclass coefficient (ICC). Segmentation accuracy and inter-reader agreement were evaluated using the dice score.Structural tissue parameters (T1, T2) showed wCV (%) between 4 and 11 and an ICC between 0.2 and 0.8. Functional parameters (ASL, BOLD and DWI) showed wCV (%) between 3 and 38 and an ICC between 0.0 and 0.7. The highest variances between test-retest scans were observed in perfusion measurements with ASL and IVIM (wCV: 17-37%). Quantitative analysis of the cortex and medulla showed a better repeatability when acquired using manual segmentation compared to ROI-based image analysis. Comparable repeatability was achieved with manual and automatic segmentation of the total kidney.Reasonable repeatability was achieved for all MR parameters. Structural MR parameters showed better repeatability compared to functional parameters. ROI-based image analysis showed overall lower repeatability compared to manual segmentation. Comparable repeatability to manual segmentation as well as acceptable segmentation accuracy could be achieved with automatic segmentation. · Reasonable test-retest repeatability can be achieved with multiparametric MRI of the kidneys.. · Image analysis based on manual segmentation of the cortex and medulla showed overall better repeatability compared to ROI-based analysis.. · Automatic segmentation of kidney volume showed similar repeatability of quantitative image analysis compared to manual segmentation.. · Liang C, Loster I, Ursprung S et al. Multiparametric functional MRI of the kidneys - evaluation of test-retest repeatability and effects of different manual and automatic image analysis strategies. Fortschr Röntgenstr 2024; DOI 10.1055/a-2480-4885.