Patient-Reported Outcomes Following Systemic Antibiotic Adjunct to Nonsurgical Treatment of Periodontitis: A Randomized Controlled Clinical Trial

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Clinical and Experimental Dental Research Pub Date : 2025-01-13 DOI:10.1002/cre2.70067
Parastoo Parhizkar, Jaber Yaghini, Omid Fakheran
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Abstract

Objectives

Considering the importance of patient-centered care, we aimed to evaluate the impact of systemic antibiotics on oral health–related quality of life during nonsurgical periodontal treatment. This controlled trial addresses a gap in understanding how systemic antibiotics influence patient-reported outcomes, focusing on Stage III periodontitis.

Materials and Methods

Sixty-one adults participated in a double-blind, randomized clinical trial, with participants divided into two groups: the test group, which received antibiotics, and the control group. All the participants received nonsurgical periodontal treatment. We conducted follow-up assessments at one and 3 months posttreatment, including recording clinical parameters and administering the Oral Health Impact Profile-14 (OHIP-14) questionnaire.

Results

The results showed a notable improvement in the quality of life for patients in the test group compared to the control group at 1 month (p value = 0.012) and 3 months (p value = 0.014) after treatment. While there were improvements in pocket probing depth, gingival index, and clinical attachment loss in both groups, it is worth noting that only bleeding on probing exhibited a significant improvement in the test group after 3 months compared to the control group (p value = 0.008).

Conclusions

In summary, incorporating systemic antibiotics alongside nonsurgical periodontal treatments appears to bring about positive outcomes for individuals dealing with Stage III periodontitis during nonsurgical treatment, ultimately enhancing their oral health-related quality of life.

Trial Registration

Iranian Registry of Clinical Trials (IRCT Id): IRCT20201221049786N1.

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患者报告的结果在全身抗生素辅助治疗牙周炎非手术治疗:一项随机对照临床试验。
目的:考虑到以患者为中心的护理的重要性,我们旨在评估非手术牙周治疗期间全身性抗生素对口腔健康相关生活质量的影响。这项对照试验解决了在理解全面性抗生素如何影响患者报告的结果方面的空白,重点是III期牙周炎。材料与方法:61名成年人参加了一项双盲随机临床试验,参与者分为两组:实验组接受抗生素治疗,对照组接受抗生素治疗。所有的参与者都接受了非手术牙周治疗。我们在治疗后1个月和3个月进行随访评估,包括记录临床参数和填写口腔健康影响问卷-14 (OHIP-14)。结果:治疗后1个月(p值= 0.012)和3个月(p值= 0.014),试验组患者的生活质量较对照组有明显改善。虽然两组在探袋深度、牙龈指数和临床附着丧失方面均有改善,但值得注意的是,3个月后,与对照组相比,试验组只有探袋出血有显著改善(p值= 0.008)。结论:综上所述,在非手术牙周治疗的同时结合全身性抗生素治疗似乎为在非手术治疗期间处理III期牙周炎的个体带来了积极的结果,最终提高了他们口腔健康相关的生活质量。试验注册:伊朗临床试验注册中心(IRCT Id): IRCT20201221049786N1。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical and Experimental Dental Research
Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.30
自引率
5.60%
发文量
165
审稿时长
26 weeks
期刊介绍: Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.
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