Isabel August, Pascal Gagneux, Katerina Semendeferi, Maria Carolina Marchetto
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引用次数: 0
Abstract
Primates rely on memory to navigate both physical and social environments and in humans, loss of memory function leads to devastating consequences. Alzheimer's disease (AD) is a neurodegenerative disease which begins by impacting memory functioning and is ultimately fatal. AD is common across human populations and its prevalence is predicted to rise with increases in the aging population. Despite this, the full AD phenotype has not been observed in any other nonhuman primate species. While a significant amount of research has been devoted to understanding the immediate mechanisms involved in AD pathogenesis in humans, less research has focused on why humans are particularly vulnerable to neurodegenerative diseases like AD. Here we explore hypotheses on the evolution of distinct human susceptibility to AD and place these in the context of findings from comparative neuroanatomical and molecular studies and discuss recent evidence for evolutionary changes protective against AD in the primate lineage.
期刊介绍：
Evolutionary Anthropology is an authoritative review journal that focuses on issues of current interest in biological anthropology, paleoanthropology, archaeology, functional morphology, social biology, and bone biology — including dentition and osteology — as well as human biology, genetics, and ecology. In addition to lively, well-illustrated articles reviewing contemporary research efforts, this journal also publishes general news of relevant developments in the scientific, social, or political arenas. Reviews of noteworthy new books are also included, as are letters to the editor and listings of various conferences. The journal provides a valuable source of current information for classroom teaching and research activities in evolutionary anthropology.
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