{"title":"Association of Interleukin-1α with periodontitis among Indians: a narrative review.","authors":"Urvi Vashistha, Nitik Baisoya, Pranav Bansal, Pranav Trishal, Ruchi Pandey","doi":"10.3205/dgkh000525","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The etiology of periodontitis is multifactorial, involving interactions between bacterial pathogens, host immune response, and environmental factors. Among the host immune factors, interleukin-1 alpha (IL-1α) has been implicated in the pathogenesis of periodontitis. Many studies have aimed to find the association between IL-1α and periodontitis in various populations worldwide. However, the evidence in the Indian population is limited. Therefore, this study aims to analyse data from the literature related to the genetic correlation between IL-1α polymorphisms and periodontitis among Indians.</p><p><strong>Method: </strong>Only case-control and cross-sectional studies investigating the association between IL-1α polymorphisms (+4,845 and -889) and various forms of periodontitis in the Indian population were included. PubMed, Medline, Web of Science, Cochrane based reviews, Scopus, and Google Scholar were used for the search.</p><p><strong>Results: </strong>The findings demonstrate a mixed pattern of associations between these polymorphisms and periodontitis across different regions of India.</p><p><strong>Conclusion: </strong>The correlation of periodontitis with IL-1α polymorphism in Indians lacks evidence.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc70"},"PeriodicalIF":1.7000,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730436/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"GMS Hygiene and Infection Control","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3205/dgkh000525","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0
Abstract
Background: The etiology of periodontitis is multifactorial, involving interactions between bacterial pathogens, host immune response, and environmental factors. Among the host immune factors, interleukin-1 alpha (IL-1α) has been implicated in the pathogenesis of periodontitis. Many studies have aimed to find the association between IL-1α and periodontitis in various populations worldwide. However, the evidence in the Indian population is limited. Therefore, this study aims to analyse data from the literature related to the genetic correlation between IL-1α polymorphisms and periodontitis among Indians.
Method: Only case-control and cross-sectional studies investigating the association between IL-1α polymorphisms (+4,845 and -889) and various forms of periodontitis in the Indian population were included. PubMed, Medline, Web of Science, Cochrane based reviews, Scopus, and Google Scholar were used for the search.
Results: The findings demonstrate a mixed pattern of associations between these polymorphisms and periodontitis across different regions of India.
Conclusion: The correlation of periodontitis with IL-1α polymorphism in Indians lacks evidence.
背景：牙周炎的病因是多因素的，涉及细菌病原体、宿主免疫反应和环境因素之间的相互作用。在宿主免疫因子中，白细胞介素-1α (IL-1α)与牙周炎的发病有关。许多研究旨在发现全球不同人群中IL-1α与牙周炎之间的关系。然而，在印度人口中的证据有限。因此，本研究旨在分析与印度人IL-1α多态性与牙周炎遗传相关性相关的文献资料。方法：仅纳入病例对照和横断面研究，调查IL-1α多态性（+4,845和-889）与印度人群各种形式的牙周炎之间的关系。PubMed, Medline, Web of Science，基于Cochrane的评论，Scopus和谷歌Scholar被用于搜索。结果：研究结果表明，这些多态性和牙周炎在印度不同地区的混合模式的关联。结论：印度人牙周炎与IL-1α多态性的相关性缺乏证据。
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