Neuronal mechanisms of nociceptive-evoked gamma-band oscillations in rodents.

IF 14.7 1区医学 Q1 NEUROSCIENCES Neuron Pub Date : 2025-03-05 Epub Date: 2025-01-13 DOI:10.1016/j.neuron.2024.12.011

Lupeng Yue, Chongyu Bao, Libo Zhang, Fengrui Zhang, Wenqian Zhou, Gian Domenico Iannetti, Li Hu

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Abstract

Gamma-band oscillations (GBOs) in the primary somatosensory cortex (S1) play key roles in nociceptive processing. Yet, one crucial question remains unaddressed: what neuronal mechanisms underlie nociceptive-evoked GBOs? Here, we addressed this question using a range of somatosensory stimuli (nociceptive and non-nociceptive), neural recording techniques (electroencephalography in humans and silicon probes and calcium imaging in rodents), and optogenetics (alone or simultaneously with electrophysiology in mice). We found that (1) GBOs encoded pain intensity independent of stimulus intensity in humans, (2) GBOs in S1 encoded pain intensity and were triggered by spiking of S1 interneurons, (3) parvalbumin (PV)-positive interneurons preferentially tracked pain intensity, and critically, (4) PV S1 interneurons causally modulated GBOs and pain-related behaviors for both thermal and mechanical pain. These findings provide causal evidence that nociceptive-evoked GBOs preferentially encoding pain intensity are generated by PV interneurons in S1, thereby laying a solid foundation for developing GBO-based targeted pain therapies.

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啮齿动物痛觉诱发伽马波段振荡的神经元机制

初级体感觉皮层（S1）的伽马波段振荡（GBOs）在伤害性加工中起着关键作用。然而，一个关键问题仍未解决：伤害性诱发的gbo背后的神经元机制是什么？在这里，我们使用一系列躯体感觉刺激（伤害性和非伤害性）、神经记录技术（人类脑电图和啮齿动物的硅探针和钙成像）和光遗传学（单独或同时与小鼠电生理学）来解决这个问题。我们发现：(1)GBOs编码疼痛强度独立于刺激强度；(2)S1区GBOs编码疼痛强度，并由S1中间神经元的峰值触发；(3)小白蛋白（PV）阳性的中间神经元优先跟踪疼痛强度；(4)PV S1中间神经元对GBOs和疼痛相关行为进行因果调节，包括热痛和机械性疼痛。这些发现提供了伤害性诱发的gbo优先编码疼痛强度是由S1的PV中间神经元产生的因果证据，从而为开发基于gbo的靶向疼痛治疗奠定了坚实的基础。

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.