Investigation of chitin grafting: thermal, antioxidant and antitumor properties

IF 5.5 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY Nanoscale Research Letters Pub Date : 2025-01-15 DOI:10.1186/s11671-025-04185-y

Nevin Çankaya, Mehmet Mürşit Temüz, Burak Can

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Abstract

In this study, firstly chitin was reacted with chloracetyl chloride to synthesize the macroinitiator chitinchloroacetate (Ch.ClAc). Then, graft copolymers of methacrylamide (MAM), diacetone acrylamide (DAAM), N-(4-nitrophenyl)acrylamide (NPA), and 2-hydroxyethyl methacrylate (HEMA) monomers were synthesized by atom transfer radical polymerization (ATRP). All of the polymers were characterized by FTIR spectra and elemental analysis. According to the elemental analysis results, the mole percent (y) of the macro initiator was found to be 17.39%. The thermal stability of all the polymers (chitin, Ch.ClAc and its graft copolymers) was determined by thermogravimetric analysis (TGA) method and the highest thermal stability was observed in the ungrafted raw chitin. DPPH• scavenging activity and antitumor activity of all polymers were then investigated. Ch.ClAc was found to be the polymer that inhibited the proliferation of tumor cells more than chitin and graft copolymers. It was observed that the antitumor (L1210 cell lines) effect increased with increasing time and concentration in all polymers.

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几丁质接枝的热、抗氧化和抗肿瘤性能研究。

本研究首先将几丁质与氯乙酰氯反应合成大引发剂几丁质氯乙酸酯（chc . clac）。然后，采用原子转移自由基聚合（ATRP）法制备了甲基丙烯酰胺（MAM）、二丙酮丙烯酰胺（DAAM）、N-（4-硝基苯基）丙烯酰胺（NPA）和甲基丙烯酸羟乙酯（HEMA）单体接枝共聚物。用FTIR光谱和元素分析对聚合物进行了表征。根据元素分析结果，该宏观引发剂的摩尔百分数(y)为17.39%。热重分析（TGA）法测定了所有聚合物（甲壳素、chc . clac及其接枝共聚物）的热稳定性，未接枝的生甲壳素的热稳定性最高。然后研究了所有聚合物的DPPH•清除活性和抗肿瘤活性。chc - clac对肿瘤细胞增殖的抑制作用优于几丁质和接枝共聚物。观察到各聚合物的抗肿瘤（L1210细胞系）作用随时间和浓度的增加而增强。

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来源期刊

Nanoscale Research Letters 工程技术-材料科学：综合

CiteScore

11.30

自引率

0.00%

发文量

110

审稿时长

48 days

期刊介绍： Nanoscale Research Letters (NRL) provides an interdisciplinary forum for communication of scientific and technological advances in the creation and use of objects at the nanometer scale. NRL is the first nanotechnology journal from a major publisher to be published with Open Access.