HBM4EU E-waste study – An untargeted metabolomics approach to characterize metabolic changes during E-waste recycling

IF 10.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environment International Pub Date : 2025-02-01 DOI:10.1016/j.envint.2025.109281

Lucyna Kozlowska , Susana Viegas , Paul T.J. Scheepers , Radu C. Duca , Lode Godderis , Carla Martins , Krzesimir Ciura , Karolina Jagiello , Maria João Silva , Selma Mahiout , Inese Mārtiņsone , Linda Matisāne , An van Nieuwenhuyse , Tomasz Puzyn , Monika Sijko-Szpanska , Jelle Verdonck , Tiina Santonen , the HBM4EU E-waste Study Team

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Abstract

E-waste contains hazardous chemicals that may be a direct health risk for workers involved in recycling. We conducted an untargeted metabolomics analysis of urine samples collected from male e-waste processing workers to explore metabolic changes associated with chemical exposures in e-waste recycling in Belgium, Finland, Latvia, Luxembourg, the Netherlands, Poland, and Portugal. Questionnaire data and urine samples were obtained from workers involved in the processing of e-waste (sorting, dismantling, shredding, pre-processing, metal, and non-metal processing), as well as from controls with no known occupational exposure. Pre- and post-shift urine samples were collected and analysed using ultrahigh-performance liquid chromatography-mass spectrometry (UPLC-MS). A total of 32 endogenous urinary metabolites were annotated with a Variable Importance in Projection (VIP) above 2, indicating that e-waste recycling is mainly associated with changes in steroid hormone and neurotransmitter metabolism, energy metabolism, bile acid biosynthesis, and inflammation. The highest VIP was observed for dopamine-o-quinone, which is linked to Parkinson’s disease. These and other changes in metabolism in workers employed in the processing of e-waste need further verification in targeted studies.

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HBM4EU电子废物研究-一种非靶向代谢组学方法，用于表征电子废物回收过程中的代谢变化

电子垃圾含有有害化学物质，可能对参与回收的工人构成直接的健康风险。我们对收集自比利时、芬兰、拉脱维亚、卢森堡、荷兰、波兰和葡萄牙的男性电子垃圾处理工人的尿液样本进行了非靶向代谢组学分析，以探索电子垃圾回收过程中化学物质暴露相关的代谢变化。问卷数据和尿液样本来自参与电子废物处理（分类、拆解、粉碎、预处理、金属和非金属处理）的工人，以及没有已知职业接触的对照组。采用超高效液相色谱-质谱（UPLC-MS）对轮班前和轮班后的尿液样本进行收集和分析。共有32种内源性尿液代谢物的投影变量重要性（VIP）标注在2以上，表明电子垃圾回收主要与类固醇激素和神经递质代谢、能量代谢、胆汁酸生物合成和炎症的变化有关。VIP最高的是多巴胺-醌，它与帕金森病有关。从事电子废物处理的工人的新陈代谢的这些和其他变化需要在有针对性的研究中进一步验证。

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.