Role of Population Based Studies in Advancing our Knowledge of Myelodysplastic Syndromes.

IF 2.7 3区医学 Q2 HEMATOLOGY Current Hematologic Malignancy Reports Pub Date : 2025-01-17 DOI:10.1007/s11899-025-00750-5

Diego A Adrianzen-Herrera, Aneta Strumlowska

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Abstract

Purpose of the review: Myelodysplastic syndromes (MDS) are myeloid neoplasms characterized by high molecular and genomic heterogeneity. Accordingly, efforts in risk assessment and therapeutic intervention mostly target unique profiles that individualize specific MDS subtypes. In this review, we explored the contributions of population based studies accounting for MDS as a group.

Recent findings: Large population based studies have been critical to define important details of our current knowledge of the disease. We summarized the most important population research contributions in MDS, focusing on its epidemiology, population risk factors, and relevant clinical associations. We discuss how these population data can provide vital insights to inform prevention measures, testing strategies, and treatment decisions. Population studies play an important role in guiding clinical and research efforts in MDS. Despite its complex molecular and genomic landscape, population data is integral to define the burden of disease, identify risk factors and clinical associations, and can help elucidate pathogenic mechanisms.

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基于人群的研究在提高我们对骨髓增生异常综合征的认识中的作用。

综述目的：骨髓增生异常综合征（MDS）是一种具有高分子和基因组异质性的髓系肿瘤。因此，风险评估和治疗干预的努力主要针对针对特定MDS亚型的独特特征。在这篇综述中，我们探讨了以人口为基础的研究对MDS作为一个群体的贡献。最近的发现：基于大量人口的研究对于确定我们目前对这种疾病的认识的重要细节至关重要。我们总结了MDS中最重要的人群研究贡献，重点是其流行病学、人群危险因素和相关的临床关联。我们将讨论这些人口数据如何为预防措施、检测策略和治疗决策提供重要见解。人群研究在MDS的临床和研究中起着重要的指导作用。尽管其复杂的分子和基因组景观，人口数据是不可或缺的，以确定疾病负担，确定风险因素和临床关联，并可以帮助阐明致病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Hematologic Malignancy Reports ONCOLOGY-HEMATOLOGY

CiteScore

6.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： his journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hematologic malignancy. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as leukemia, lymphoma, myeloma, and T-cell and other lymphoproliferative malignancies. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.