Optofluidic paper-based analytical device for discriminative detection of organic substances via digital color coding.

IF 7.3 1区工程技术 Q1 INSTRUMENTS & INSTRUMENTATION Microsystems & Nanoengineering Pub Date : 2025-01-16 DOI:10.1038/s41378-024-00865-4

Jinsol Choi, Chi Yeung Oh, Gong Qian, Tae Soup Shim, Heon-Ho Jeong

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Abstract

Developing a portable yet affordable method for the discrimination of chemical substances with good sensitivity and selectivity is essential for on-site visual detection of unknown substances. Herein, we propose an optofluidic paper-based analytical device (PAD) that consists of a macromolecule-driven flow (MDF) gate and photonic crystal (PhC) coding units, enabling portable and scalable detection and discrimination of various organic chemical, mimicking the olfactory system. The MDF gate is designed for precise flow control of liquid analytes, which depends on intermolecular interactions between the polymer at the MDF gate and the liquid analytes. Subsequently, the PhC coding unit allows for visualizing the result obtained from the MDF gate and generating differential optical patterns. We fabricate an optofluidic PAD by integrating two coding units into a three-dimensional (3D) microfluidic paper within a 3D-printed cartridge. The optofluidic PADs clearly distinguish 11 organic chemicals with digital readout of pattern recognition from colorimetric signals. We believe that our optofluidic coding strategy mimicking the olfactory system opens up a wide range of potential applications in colorimetric monitoring of chemicals observed in environment.

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通过数字颜色编码判别检测有机物质的光流纸质分析装置。

开发一种便携且经济实惠的化学物质鉴别方法，具有良好的灵敏度和选择性，对于未知物质的现场视觉检测至关重要。在此，我们提出了一种由大分子驱动流（MDF）门和光子晶体（PhC）编码单元组成的光流体纸基分析装置（PAD），可以模拟嗅觉系统，实现便携式和可扩展的各种有机化学检测和识别。MDF门设计用于液体分析物的精确流动控制，这取决于MDF门和液体分析物的聚合物之间的分子间相互作用。随后，PhC编码单元允许可视化从MDF门获得的结果并生成微分光学图案。我们通过将两个编码单元集成到3D打印墨盒内的三维（3D）微流控纸中来制造光流体PAD。光流体PADs清晰地区分了11种有机化学品与模式识别的数字读出比色信号。我们相信我们的模拟嗅觉系统的光流编码策略在环境中观察到的化学物质的比色监测中开辟了广泛的潜在应用。

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来源期刊

Microsystems & Nanoengineering Materials Science-Materials Science (miscellaneous)

CiteScore

12.00

自引率

3.80%

发文量

123

审稿时长

20 weeks

期刊介绍： Microsystems & Nanoengineering is a comprehensive online journal that focuses on the field of Micro and Nano Electro Mechanical Systems (MEMS and NEMS). It provides a platform for researchers to share their original research findings and review articles in this area. The journal covers a wide range of topics, from fundamental research to practical applications. Published by Springer Nature, in collaboration with the Aerospace Information Research Institute, Chinese Academy of Sciences, and with the support of the State Key Laboratory of Transducer Technology, it is an esteemed publication in the field. As an open access journal, it offers free access to its content, allowing readers from around the world to benefit from the latest developments in MEMS and NEMS.