The repeatability of macular and peripapillary vessel density in participants with different severities of glaucoma.

IF 2.8 3区 医学 Q1 OPHTHALMOLOGY Ophthalmic and Physiological Optics Pub Date : 2025-01-17 DOI:10.1111/opo.13448
Yun Hsia, Tsing-Hong Wang, Jehn-Yu Huang, Chien-Chia Su
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Abstract

Purpose: To investigate the repeatability of optical coherence tomography angiography (OCTA) parameters in participants with different severities of glaucoma.

Methods: Subjects with open-angle glaucoma were enrolled prospectively and categorised into mild (mean deviation [MD] of 24-2 visual field test ≥ -6 dB), moderate to advanced (-6 > MD ≥ -20 dB) and severe glaucoma groups (MD < -20 dB). OCTA was performed three times within a single visit to obtain superficial and deep macular vessel density (VD) and peripapillary vessel and capillary density. The association between the coefficient of variation (CoV) and intraclass correlation coefficient (ICC) of these OCTA parameters and glaucoma severity (MD, the thickness of the retinal nerve fibre layer and the ganglion cell complex) was analysed, along with factors associated with the CoV of OCTA parameters.

Results: A total of 57 mild, 92 moderate to advanced and 39 severe glaucomatous eyes were included. CoV for superficial (p < 0.001) and deep macular VD (p < 0.001) and peripapillary VD (p = 0.004) increased with glaucoma severity. Greater CoV for superficial and deep macular VD and peripapillary VD was associated with worse MD and scan quality index in multivariable analysis. The association between a higher CoV of superficial and deep macular VD and worse MD was only noticeable in participants with a scan quality index <7. The relationship between the CoV of peripapillary VD and MD was consistent across varying image qualities.

Conclusion: The intrasession variability of OCTA parameters was greater in glaucoma participants with advanced disease, especially in those with suboptimal scan quality.

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不同程度青光眼患者黄斑和乳头周围血管密度的可重复性。
目的:探讨不同程度青光眼患者光学相干断层血管造影(OCTA)参数的可重复性。方法:前瞻性纳入开角型青光眼患者,分为轻度(24-2视野测试平均偏差[MD]≥-6 dB)、中晚期(-6 > MD≥-20 dB)和重度青光眼组(MD)。结果:共纳入57只轻度、92只中晚期和39只重度青光眼。结论:晚期青光眼患者,特别是扫描质量不理想的青光眼患者,OCTA参数的浸润内变异性更大。
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来源期刊
CiteScore
5.10
自引率
13.80%
发文量
135
审稿时长
6-12 weeks
期刊介绍: Ophthalmic & Physiological Optics, first published in 1925, is a leading international interdisciplinary journal that addresses basic and applied questions pertinent to contemporary research in vision science and optometry. OPO publishes original research papers, technical notes, reviews and letters and will interest researchers, educators and clinicians concerned with the development, use and restoration of vision.
期刊最新文献
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