Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders.

IF 3.9 4区医学 Q1 PSYCHIATRY World Journal of Psychiatry Pub Date : 2025-01-19 DOI:10.5498/wjp.v15.i1.97945

Heng Liao, Sha Liao, Yu-Jiao Gao, Xi Wang, Li-Hong Guo, Su Zheng, Wu Yang, Yi-Nan Dai

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Abstract

Background: Mild cognitive impairment (MCI) has a high risk of progression to Alzheimer's disease. The disease is often accompanied by sleep disorders, and whether sleep disorders have an effect on brain function in patients with MCI is unclear.

Aim: To explore the near-infrared brain function characteristics of MCI with sleep disorders.

Methods: A total of 120 patients with MCI (MCI group) and 50 healthy subjects (control group) were selected. All subjects underwent the functional near-infrared spectroscopy test. Collect baseline data, Mini-Mental State Examination, Montreal Cognitive Assessment scale, fatigue severity scale (FSS) score, sleep parameter, and oxyhemoglobin (Oxy-Hb) concentration and peak time of functional near-infrared spectroscopy test during the task period. The relationship between Oxy-Hb concentration and related indexes was analyzed by Pearson or Spearmen correlation.

Results: Compared with the control group, the FSS score of the MCI group was higher (t = 11.310), and the scores of Pittsburgh sleep quality index, sleep time, sleep efficiency, nocturnal sleep disturbance, and daytime dysfunction were higher (Z = -10.518, -10.368, -9.035, -10.661, -10.088). Subjective sleep quality and total sleep time scores were lower (Z = -11.592, -9.924). The sleep efficiency of the MCI group was lower, and the awakening frequency, rem sleep latency period, total sleep time, and oxygen desaturation index were higher (t = 5.969, 5.829, 2.887, 3.003, 5.937). The Oxy-Hb concentration at T0, T1, and T2 in the MCI group was lower (t = 14.940, 11.280, 5.721), and the peak time was higher (t = 18.800, 13.350, 9.827). In MCI patients, the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index, sleep time, total sleep time, and sleep efficiency (r = -0.611, -0.388, -0.563, -0.356). It was positively correlated with sleep efficiency and total sleep time (r = 0.754, 0.650), and negatively correlated with oxygen desaturation index (r = -0.561) and FSS score (r = -0.526). All comparisons were P < 0.05.

Conclusion: Patients with MCI and sleep disorders have lower near-infrared brain function than normal people, which is related to sleep quality. Clinically, a comprehensive assessment of the near-infrared brain function of patients should be carried out to guide targeted treatment and improve curative effect.

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轻度认知障碍伴睡眠障碍的近红外脑功能特征。

背景：轻度认知障碍（MCI）发展为阿尔茨海默病的风险很高。该病常伴有睡眠障碍，睡眠障碍是否对轻度认知障碍患者的脑功能有影响尚不清楚。目的：探讨轻度认知损伤伴睡眠障碍的近红外脑功能特征。方法：选取120例轻度认知损伤患者（MCI组）和50例健康受试者（对照组）。所有受试者均进行功能性近红外光谱测试。收集任务期间基线数据、精神状态量表、蒙特利尔认知评估量表、疲劳严重程度量表（FSS）评分、睡眠参数、功能性近红外光谱测试血红蛋白（Oxy-Hb）浓度及峰值时间。采用Pearson或spearman相关分析Oxy-Hb浓度与相关指标的关系。结果：与对照组相比，MCI组FSS评分较高（t = 11.310），匹兹堡睡眠质量指数、睡眠时间、睡眠效率、夜间睡眠障碍、日间功能障碍评分较高（Z = -10.518、-10.368、-9.035、-10.661、-10.088）。主观睡眠质量和总睡眠时间得分较低（Z = -11.592, -9.924）。MCI组睡眠效率较低，唤醒频率、rem睡眠潜伏期、总睡眠时间、氧去饱和指数较高（t = 5.969、5.829、2.887、3.003、5.937）。MCI组在T0、T1、T2时Oxy-Hb浓度较低（t = 14.940、11.280、5.721），峰值时间较高（t = 18.800、13.350、9.827）。MCI患者T0时Oxy-Hb浓度与匹兹堡睡眠质量指数、睡眠时间、总睡眠时间、睡眠效率得分呈负相关（r = -0.611, -0.388, -0.563, -0.356）。与睡眠效率、总睡眠时间呈正相关（r = 0.754、0.650），与氧去饱和指数（r = -0.561）、FSS评分呈负相关（r = -0.526）。所有比较P < 0.05。结论：轻度认知损伤合并睡眠障碍患者近红外脑功能低于正常人，这与睡眠质量有关。临床上应对患者近红外脑功能进行综合评估，指导针对性治疗，提高疗效。

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来源期刊

World Journal of Psychiatry PSYCHIATRY-

自引率

6.50%

发文量

110

期刊介绍： The World Journal of Psychiatry (WJP) is a high-quality, peer reviewed, open-access journal. The primary task of WJP is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of psychiatry. In order to promote productive academic communication, the peer review process for the WJP is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJP are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in psychiatry.