{"title":"Effective Target Sites in Thalamic Stimulation for Focal Hand Dystonia.","authors":"Takao Hashimoto, Jun Tanimura, Takehiro Yako","doi":"10.1159/000543478","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Functional thalamic surgery is known for alleviating isolated focal hand dystonia; however, the optimal target site in the thalamus is not determined. This study aimed to identify effective sites for thalamic deep brain stimulation (DBS) in treating this condition.</p><p><strong>Methods: </strong>Four patients presenting with focal hand dystonia underwent thalamic DBS. Effective stimulation sites were identified through a combination of physiological and radiological mapping.</p><p><strong>Results: </strong>All patients exhibited significant improvement in their hand dystonia. The most effective stimulation sites were localized in the anterior regions of the ventral intermedius nucleus (Vim), involving both Vim and the ventro-oral nucleus (VO).</p><p><strong>Conclusion: </strong>Thalamic DBS proves highly effective in managing focal hand dystonia. The identified effective stimulation sites suggest the involvement of both the pallidothalamocortical and cerebellothalamocortical pathways in its pathophysiology.</p>","PeriodicalId":22078,"journal":{"name":"Stereotactic and Functional Neurosurgery","volume":" ","pages":"1-11"},"PeriodicalIF":1.9000,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Stereotactic and Functional Neurosurgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000543478","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROIMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Functional thalamic surgery is known for alleviating isolated focal hand dystonia; however, the optimal target site in the thalamus is not determined. This study aimed to identify effective sites for thalamic deep brain stimulation (DBS) in treating this condition.
Methods: Four patients presenting with focal hand dystonia underwent thalamic DBS. Effective stimulation sites were identified through a combination of physiological and radiological mapping.
Results: All patients exhibited significant improvement in their hand dystonia. The most effective stimulation sites were localized in the anterior regions of the ventral intermedius nucleus (Vim), involving both Vim and the ventro-oral nucleus (VO).
Conclusion: Thalamic DBS proves highly effective in managing focal hand dystonia. The identified effective stimulation sites suggest the involvement of both the pallidothalamocortical and cerebellothalamocortical pathways in its pathophysiology.
期刊介绍：
''Stereotactic and Functional Neurosurgery'' provides a single source for the reader to keep abreast of developments in the most rapidly advancing subspecialty within neurosurgery. Technological advances in computer-assisted surgery, robotics, imaging and neurophysiology are being applied to clinical problems with ever-increasing rapidity in stereotaxis more than any other field, providing opportunities for new approaches to surgical and radiotherapeutic management of diseases of the brain, spinal cord, and spine. Issues feature advances in the use of deep-brain stimulation, imaging-guided techniques in stereotactic biopsy and craniotomy, stereotactic radiosurgery, and stereotactically implanted and guided radiotherapeutics and biologicals in the treatment of functional and movement disorders, brain tumors, and other diseases of the brain. Background information from basic science laboratories related to such clinical advances provides the reader with an overall perspective of this field. Proceedings and abstracts from many of the key international meetings furnish an overview of this specialty available nowhere else. ''Stereotactic and Functional Neurosurgery'' meets the information needs of both investigators and clinicians in this rapidly advancing field.
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