Magnetically driven wireless implantable interface polarization-enhanced triboelectric nanogenerator for promoting neural cell differentiation

Abstract

The advancement of implantable electronic devices has significantly improved medical diagnostics, therapeutics, and regenerative medicine. To realize the trend of unwired, simple-operation and high-safety, electronic implantation. We developed an implantable magnetic driving TENG (IMD-TENG) with a zero-Poisson's-ratio design, which processes a novel biodegradable and biocompatible PVA-chitosan (PVA-CS) aerogel by exploiting interface polarization. The electrical performance of CS-based TENGs, achieving an open circuit voltage of 1431 V, and a short circuit current density of 3.88 μA cm^-2. Leveraging the PVA-CS aerogel's excellent biocompatibility and degradability, IMD-TENG was applied in vivo energy supply and electrical stimulation. The results demonstrated the IMD-TENG's compatibility with biological tissues and stable output, along with positive effects on the growth and neurite elongation of SH-SY5Y neuron cells, promoting neuronal maturation and increased Tau protein expression. This innovative approach provides a new avenue for developing implantable bioelectronic devices, with potential applications in treating neurodegenerative diseases and advancing nerve tissue engineering.