A novel method for detecting intracranial pressure changes by monitoring cerebral perfusion via electrical impedance tomography.

IF 5.9 1区 医学 Q1 NEUROSCIENCES Fluids and Barriers of the CNS Pub Date : 2025-01-23 DOI:10.1186/s12987-025-00619-y
Ming-Xu Zhu, Jun-Yao Li, Zhan-Xiu Cai, Yu Wang, Wei-Ce Wang, Yi-Tong Guo, Guo-Bin Gao, Qing-Dong Guo, Xue-Tao Shi, Wei-Chen Li
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Abstract

Background: Acute and critical neurological diseases are often accompanied with elevated intracranial pressure (ICP), leading to insufficient cerebral perfusion, which may cause severe secondary lesion. Existing ICP monitoring techniques often fail to effectively meet the demand for real-time noninvasive ICP monitoring and warning. This study aimed to explore the use of electrical impedance tomography (EIT) to provide real-time early warning of elevated ICP by observing cerebral perfusion.

Methods: An intracranial hypertension model was prepared by injecting autologous un-anticoagulated blood into the brain parenchyma of twelve Landrace swine. Invasive ICP monitoring was used as a control method, and a high-precision EIT system was used to acquire and analyze the changing patterns of cerebral perfusion EIT image parameters with respect to ICP. Four EIT parameters related to cerebral perfusion were extracted from the images, and their potential application in detecting ICP elevation was analyzed.

Results: When ICP increased, all EIT perfusion parameters decreased significantly (P < 0.05). When the subjects were in a state of intracranial hypertension (ICP > 22 mmHg), the correlation between EIT perfusion parameters and ICP was more significant (P < 0.01), with correlation coefficients ranging from -0.72 to -0.83. We tested the objects when they were in baseline ICP and in ICP of 15-40 mmHg. Under both circumstances, ROC curve analysis showed that the comprehensive model of perfusion parameters based on the random forest algorithm had a sensitivity and specificity of more than 90% and an area under the curve (AUC) of more than 0.9 for detecting ICP increments of both 5 and 10 mmHg.

Conclusion: This study demonstrates the feasibility of using perfusion EIT to detect ICP increases in real time, which may provide a new method for real-time non-invasive monitoring of patients with increased ICP.

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来源期刊
Fluids and Barriers of the CNS
Fluids and Barriers of the CNS Neuroscience-Developmental Neuroscience
CiteScore
10.70
自引率
8.20%
发文量
94
审稿时长
14 weeks
期刊介绍: "Fluids and Barriers of the CNS" is a scholarly open access journal that specializes in the intricate world of the central nervous system's fluids and barriers, which are pivotal for the health and well-being of the human body. This journal is a peer-reviewed platform that welcomes research manuscripts exploring the full spectrum of CNS fluids and barriers, with a particular focus on their roles in both health and disease. At the heart of this journal's interest is the cerebrospinal fluid (CSF), a vital fluid that circulates within the brain and spinal cord, playing a multifaceted role in the normal functioning of the brain and in various neurological conditions. The journal delves into the composition, circulation, and absorption of CSF, as well as its relationship with the parenchymal interstitial fluid and the neurovascular unit at the blood-brain barrier (BBB).
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