Research priorities for non-invasive therapies to improve hydrocephalus outcomes.

IF 6.2 1区医学 Q1 NEUROSCIENCES Fluids and Barriers of the CNS Pub Date : 2025-03-03 DOI:10.1186/s12987-025-00632-1

Alexandra Hochstetler, Christine Hehnly, William Dawes, Daniel Harris, Cameron Sadegh, Francesco T Mangano, Samantha N Lanjewar, Monica J Chau

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Abstract

The Hydrocephalus Association organized two workshops with the support of the Rudi Schulte Research Institute and Cincinnati Children's Hospital Medical Center entitled "Developing Non-Invasive Hydrocephalus Therapies: Molecular and Cellular Targets", held September 27-29, 2023, in Dallas, TX, and "Developing Non-Invasive Hydrocephalus Therapies: Advancing Towards Clinical Trials", held April 12-13, 2024, in Cincinnati, OH. The goal of these workshops was to explore the frontiers of ongoing research for non-invasive therapies for the treatment of hydrocephalus across all etiologies and to improve patient outcomes at all stages of diagnosis and management. During the consensus-building discussions throughout the research workshops, basic, translational, and clinical scientists aimed to identify the next steps to develop novel treatments for hydrocephalus. This detailed report discusses the research priorities that emerged from these workshops to inspire researchers and guide studies towards better treatment for people living with hydrocephalus.

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改善脑积水预后的非侵入性治疗的研究重点。

脑积水协会在鲁迪舒尔特研究所和辛辛那提儿童医院医疗中心的支持下组织了两次研讨会，题为“开发非侵入性脑积水疗法：分子和细胞靶点”，于2023年9月27日至29日在德克萨斯州达拉斯举行，以及“开发非侵入性脑积水疗法：推进临床试验”，于2024年4月12日至13日在俄亥俄州辛辛那提举行。这些研讨会的目的是探索所有病因脑积水非侵入性治疗的前沿研究，并改善患者在诊断和治疗的各个阶段的预后。在整个研究研讨会期间建立共识的讨论中，基础、转化和临床科学家旨在确定开发脑积水新疗法的下一步措施。这份详细的报告讨论了从这些研讨会中产生的研究重点，以激励研究人员并指导研究如何更好地治疗脑积水患者。

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来源期刊

Fluids and Barriers of the CNS Neuroscience-Developmental Neuroscience

CiteScore

10.70

自引率

8.20%

发文量

审稿时长

14 weeks

期刊介绍： "Fluids and Barriers of the CNS" is a scholarly open access journal that specializes in the intricate world of the central nervous system's fluids and barriers, which are pivotal for the health and well-being of the human body. This journal is a peer-reviewed platform that welcomes research manuscripts exploring the full spectrum of CNS fluids and barriers, with a particular focus on their roles in both health and disease. At the heart of this journal's interest is the cerebrospinal fluid (CSF), a vital fluid that circulates within the brain and spinal cord, playing a multifaceted role in the normal functioning of the brain and in various neurological conditions. The journal delves into the composition, circulation, and absorption of CSF, as well as its relationship with the parenchymal interstitial fluid and the neurovascular unit at the blood-brain barrier (BBB).