Brain changes in sleep-related hypermotor epilepsy observed from wakefulness and N2 sleep: A matched case-control study

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2025-03-01 Epub Date: 2025-01-20 DOI:10.1016/j.clinph.2024.12.020

Changqiong Zhou , Chenxi Qiu , Chunge Pan , Yan Li , Yingying Tang , Ziyi Chen , Ying Liu , Sijia Guo , Jing Lu , Bo Yan , Xiaoting Hao

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Abstract

Objective

Sleep-related hypermotor epilepsy (SHE) is a relatively uncommon epilepsy syndrome, characterized by seizures closely related to the sleep cycle. This study aims to explore interictal electroencephalographic (EEG) characteristics in SHE.

Methods

We compared EEG data from 20 patients with SHE, 20 patients with focal epilepsy (FE), and 14 healthy controls, carefully matched for age, sex, education level, epilepsy duration, and drug-resistant epilepsy.

Results

Our findings revealed distinct patterns of power spectral density in SHE patients during wakefulness and N2 sleep compared to other groups, suggesting potential diagnostic value. During wakefulness, SHE patients showed enhanced frontal lobe power across all frequency bands, but decreased frontal lobe power in low-frequency bands during N2 sleep. Additionally, a positive correlation was found between frontal γ band power and epilepsy duration in SHE patients during N2 sleep but not during wakefulness.

Conclusions

These findings suggest that interictal EEG abnormalities during wakefulness and N2 sleep might be used as potential biomarkers for the diagnosis of SHE.

Significance

This study is the first to simultaneously characterize EEG during sleep and wakefulness in SHE patients during interictal periods, with potential utility for diagnosis.

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从清醒和N2睡眠观察睡眠相关的多运动性癫痫的大脑变化：一项匹配的病例对照研究。

目的：睡眠相关性多运动性癫痫（SHE）是一种较为少见的癫痫综合征，其特点是癫痫发作与睡眠周期密切相关。本研究旨在探讨脑电图间期特征。方法：我们比较了20例SHE患者、20例局灶性癫痫（FE）患者和14例健康对照者的脑电图数据，这些患者在年龄、性别、教育程度、癫痫持续时间和耐药癫痫方面进行了仔细匹配。结果：我们的研究结果显示，与其他组相比，SHE患者在清醒和N2睡眠时的功率谱密度模式明显不同，提示潜在的诊断价值。在清醒状态下，SHE患者在N2睡眠时，所有频段的额叶功率均增强，但在低频频段的额叶功率下降。此外，脑电图患者在N2睡眠时额叶γ波段功率与癫痫持续时间呈正相关，而在清醒状态时则无相关。结论：这些发现提示清醒和N2睡眠间期脑电图异常可能作为SHE诊断的潜在生物标志物。意义：本研究首次同时描述了SHE患者睡眠和清醒间期的脑电图特征，具有潜在的诊断价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.