Radiofrequency evoked potentials: A new window into the nociceptive system

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY Clinical Neurophysiology Pub Date : 2025-01-20 DOI:10.1016/j.clinph.2024.12.022

Christian Ariel Mista , Elizabeth Loreley Young , Silvio Jorge Laugero , José Alberto Biurrun Manresa

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Abstract

Objective

To describe the cortical evoked potentials in response to radiofrequency stimulation (RFEPs) in human volunteers.

Methods

Seventeen healthy volunteers participated in an experimental session in which radiofrequency (RF) and electrical (ES) stimulation were applied to the dorsum of the hands and feet. EEG was recorded to evaluate evoked responses for each stimulus modality and stimulation site.

Results

Electrophysiological results showed highly synchronous responses compatible with activation of heat-sensitive nociceptors. Latencies of the N2 and P2 peaks in the RFEPs were longer compared to EPs evoked by ES. Furthermore, the latency of the P2 peak was also longer after stimulation of the feet compared to the hand.

Conclusions

RF stimulation is capable of selective activation of nociceptive fibres by means of rapid skin heating. RFEPs showed the highest degree of synchronicity achieved to date for evoked cortical responses to thermal stimulation.

Significance

RF stimulation represents a viable alternative in the experimental and clinical assessment of the nociceptive system.

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.