The Interplay Between Gut Microbiota, Adipose Tissue, and Migraine: A Narrative Review.

IF 5 2区医学 Q1 NUTRITION & DIETETICS Nutrients Pub Date : 2025-01-18 DOI:10.3390/nu17020337

Valentina Biagioli, Federica Mela, Paola Ferraro, Gianmichele Villano, Alessandro Orsini, Maria Cristina Diana, Pasquale Striano, Andrea Santangelo

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Abstract

Background: Migraine, a prevalent neurovascular disorder, affects millions globally and is associated with significant morbidity. Emerging evidence suggests a crucial role of the gut microbiota and adipose tissue in the modulation of migraine pathophysiology, particularly through mechanisms involving neuroinflammation and metabolic regulation.

Material and methods: A narrative review of the literature from 2000 to 2024 was conducted using the PubMed database. Studies addressing the relationships between microbiota, adipose tissue, and migraine-including dietary interventions and their impact-were analyzed.

Results: The findings highlight a bidirectional gut-brain axis, with gut microbiota influencing neuroinflammation via metabolites such as short-chain fatty acids (SCFAs). Obesity exacerbates migraine severity through chronic inflammation and the dysregulation of adipocytokines like leptin and adiponectin. Dietary patterns, such as low glycemic index diets and Mediterranean diets, and the use of prebiotics, probiotics, and postbiotics show potential in migraine management.

Conclusions: This review underscores the need for integrative approaches targeting the microbiota-gut-brain axis and adipose tissue in migraine therapy. Future studies should explore longitudinal effects and personalized interventions to optimize outcomes.

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肠道微生物群、脂肪组织和偏头痛之间的相互作用：一个叙述性的回顾。

背景：偏头痛是一种普遍存在的神经血管疾病，影响着全球数百万人，并伴有显著的发病率。新出现的证据表明，肠道微生物群和脂肪组织在偏头痛病理生理调节中起着至关重要的作用，特别是通过涉及神经炎症和代谢调节的机制。材料和方法：使用PubMed数据库对2000年至2024年的文献进行叙述性回顾。分析了微生物群、脂肪组织和偏头痛之间关系的研究，包括饮食干预及其影响。结果：研究结果强调了双向肠-脑轴，肠道微生物群通过代谢物如短链脂肪酸（SCFAs）影响神经炎症。肥胖通过慢性炎症和脂肪细胞因子如瘦素和脂联素的失调加剧了偏头痛的严重程度。饮食模式，如低血糖指数饮食和地中海饮食，以及益生元、益生菌和后益生菌的使用显示出偏头痛治疗的潜力。结论：这篇综述强调了偏头痛治疗中针对微生物-肠-脑轴和脂肪组织的综合方法的必要性。未来的研究应探索纵向效应和个性化干预以优化结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrients NUTRITION & DIETETICS-

CiteScore

9.20

自引率

15.30%

发文量

4599

审稿时长

16.74 days

期刊介绍： Nutrients (ISSN 2072-6643) is an international, peer-reviewed open access advanced forum for studies related to Human Nutrition. It publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.