Prevalence of synchronous bilateral/contralateral tonsil carcinoma: A systematic review and meta-analysis

IF 3.9 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral oncology Pub Date : 2025-01-23 DOI:10.1016/j.oraloncology.2025.107180

Alex Charlton , Zahir Mughal , Florida Sharin , Raguwinder Bindy Sahota , Mohammed Shaji Mansuri , Manish Mair

{"title":"Prevalence of synchronous bilateral/contralateral tonsil carcinoma: A systematic review and meta-analysis","authors":"Alex Charlton , Zahir Mughal , Florida Sharin , Raguwinder Bindy Sahota , Mohammed Shaji Mansuri , Manish Mair","doi":"10.1016/j.oraloncology.2025.107180","DOIUrl":null,"url":null,"abstract":"<div><div>The purpose of this systematic review and <em>meta</em>-analysis was to identify the prevalence of synchronous contralateral tonsil carcinoma (SCTC) amongst patients with tonsil carcinoma or head and neck squamous cell carcinoma of unknown primary (HNSCCUP). Thirteen retrospective studies, comprising 2623 patients, were analysed, revealing an overall pooled SCTC prevalence of 4%, rising to 10% in HNSCCUP cases. HPV/p16 positivity was associated with SCTC prevalence of 3%, while HPV/p16 negativity was greater at 8%. Clinical or imaging evaluations often missed SCTC preoperatively, emphasising the importance of contralateral tonsillectomy. Morbidity varied among patients undergoing contralateral tonsillectomy.</div><div>The prevalence of SCTC is significant in cases of HNSCCUP and tonsil malignancy, emphasising the importance of informed discussions regarding contralateral tonsillectomy. Tailored approaches considering individual patient and tumour characteristics are crucial, with contralateral tonsillectomy generally warranted in HNSCCUP. Further research, including prospective studies with standardised protocols, is needed to improve the understanding and management of SCTC, specifically the clinical significance of occult SCTC.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"162 ","pages":"Article 107180"},"PeriodicalIF":3.9000,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral oncology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1368837525000090","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

The purpose of this systematic review and meta-analysis was to identify the prevalence of synchronous contralateral tonsil carcinoma (SCTC) amongst patients with tonsil carcinoma or head and neck squamous cell carcinoma of unknown primary (HNSCCUP). Thirteen retrospective studies, comprising 2623 patients, were analysed, revealing an overall pooled SCTC prevalence of 4%, rising to 10% in HNSCCUP cases. HPV/p16 positivity was associated with SCTC prevalence of 3%, while HPV/p16 negativity was greater at 8%. Clinical or imaging evaluations often missed SCTC preoperatively, emphasising the importance of contralateral tonsillectomy. Morbidity varied among patients undergoing contralateral tonsillectomy.

The prevalence of SCTC is significant in cases of HNSCCUP and tonsil malignancy, emphasising the importance of informed discussions regarding contralateral tonsillectomy. Tailored approaches considering individual patient and tumour characteristics are crucial, with contralateral tonsillectomy generally warranted in HNSCCUP. Further research, including prospective studies with standardised protocols, is needed to improve the understanding and management of SCTC, specifically the clinical significance of occult SCTC.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

同步双侧/对侧扁桃体癌的患病率：一项系统回顾和荟萃分析。

本系统综述和荟萃分析的目的是确定扁桃体癌或头颈部未知原发鳞状细胞癌（HNSCCUP）患者中同步对侧扁桃体癌（SCTC）的患病率。我们分析了13项回顾性研究，包括2623例患者，结果显示SCTC的总患病率为4%，在HNSCCUP病例中上升到10%。HPV/p16阳性与SCTC患病率相关，为3%，而HPV/p16阴性与SCTC患病率相关，为8%。术前的临床或影像学评估经常遗漏SCTC，强调对侧扁桃体切除术的重要性。对侧扁桃体切除术患者的发病率各不相同。在HNSCCUP和扁桃体恶性肿瘤的病例中，SCTC的患病率是显著的，强调了关于对侧扁桃体切除术的知情讨论的重要性。考虑个体患者和肿瘤特征的量身定制的方法是至关重要的，在HNSCCUP中通常需要对侧扁桃体切除术。需要进一步的研究，包括标准化方案的前瞻性研究，以提高对SCTC的认识和管理，特别是隐匿性SCTC的临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Oral oncology 医学-牙科与口腔外科

CiteScore

8.70

自引率

10.40%

发文量

505

审稿时长

20 days

期刊介绍： Oral Oncology is an international interdisciplinary journal which publishes high quality original research, clinical trials and review articles, editorials, and commentaries relating to the etiopathogenesis, epidemiology, prevention, clinical features, diagnosis, treatment and management of patients with neoplasms in the head and neck. Oral Oncology is of interest to head and neck surgeons, radiation and medical oncologists, maxillo-facial surgeons, oto-rhino-laryngologists, plastic surgeons, pathologists, scientists, oral medical specialists, special care dentists, dental care professionals, general dental practitioners, public health physicians, palliative care physicians, nurses, radiologists, radiographers, dieticians, occupational therapists, speech and language therapists, nutritionists, clinical and health psychologists and counselors, professionals in end of life care, as well as others interested in these fields.