Pub Date : 2024-11-16DOI: 10.1016/j.oraloncology.2024.107055
Pai Pang, Xiaomeng Xue, Zhongfei Xu, Weiyi Duan, Fayu Liu, Xuexin Tan, Enjiao Zhang, Zhongzheng Qi , Changfu Sun
The lip is a crucial structure in the oral and maxillofacial region, serving vital physiological functions such as speech, swallowing, chewing, and expression. Due to the complexity of lip anatomy, function, and the various types of defects, the functional restoration and reconstruction of lip defects remain complex and challenging tasks. In this article, we summarize several methods for functional restoration and reconstruction of lip defects using local flaps that carry the depressor anguli oris muscle, as well as some free flaps. We also introduce methods for repairing extensive defects in the oral and maxillofacial region that are accompanied by lip defects using combinations of various tissue flaps.
{"title":"Functional reconstruction of lip defects","authors":"Pai Pang, Xiaomeng Xue, Zhongfei Xu, Weiyi Duan, Fayu Liu, Xuexin Tan, Enjiao Zhang, Zhongzheng Qi , Changfu Sun","doi":"10.1016/j.oraloncology.2024.107055","DOIUrl":"10.1016/j.oraloncology.2024.107055","url":null,"abstract":"<div><div>The lip is a crucial structure in the oral and maxillofacial region, serving vital physiological functions such as speech, swallowing, chewing, and expression. Due to the complexity of lip anatomy, function, and the various types of defects, the functional restoration and reconstruction of lip defects remain complex and challenging tasks. In this article, we summarize several methods for functional restoration and reconstruction of lip defects using local flaps that carry the depressor anguli oris muscle, as well as some free flaps. We also introduce methods for repairing extensive defects in the oral and maxillofacial region that are accompanied by lip defects using combinations of various tissue flaps.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107055"},"PeriodicalIF":4.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-16DOI: 10.1016/j.oraloncology.2024.107104
Fariba Esperouz , Vito Carlo Alberto Caponio , Andrea Santarelli , Andrea Ballini , Lorenzo Lo Muzio , Domenico Ciavarella , Lucio Lo Russo
Objectives
To investigate the accuracy of ultrasound in the quantification of tumor thickness (TT) and depth of invasion (DOI) of oral potentially malignant disorders and oral squamous cell carcinoma.
Materials and methods
A systematic review search was conducted in PubMed, Scopus, and Web of Science to answer the PICO question: “What is the correlation and the mean difference between ultrasound and histopathological assessment of tumor thickness and depth of invasion in patients with oral squamous cell carcinoma and oral potentially malignant disorders? The risk of bias was assessed, meta-analysis and trial sequential analysis was conducted on the available quantitative data, followed by trial sequential analysis.
Results
Of 2089 results, 48 studies were considered suitable for inclusion.
Meta-analysis showed a low heterogeneity for tumor thickness mean difference (I2 = 0.00 %) with an overall standardized mean difference (SMD) of 0.13 (95 % CI: −0.07 to 0.33, p = 0.214). Tumor thickness correlation showed high heterogeneity (I2 = 93.41 %). For depth of invasion, the mean difference had moderate heterogeneity (I2 = 8.98 %) with an overall SMD of 0.27 (95 % CI: 0.06 to 0.48, p = 0.013). However, correlation analysis showed moderate heterogeneity (I2 = 56.22 %). Trial sequential analysis confirmed the tumor thickness results but indicated more studies are required for depth of invasion to meet the required information size.
Conclusion
There were no statistically significant differences between the results of ultrasound and histological examination, the clinical use of this device cannot yet be confirmed.
{"title":"Are we ready to use ultrasounds in the clinical assessment of depth of invasion and tumor thickness in oral squamous cell carcinoma? Results from a systematic review, meta-analysis and trial sequential analysis","authors":"Fariba Esperouz , Vito Carlo Alberto Caponio , Andrea Santarelli , Andrea Ballini , Lorenzo Lo Muzio , Domenico Ciavarella , Lucio Lo Russo","doi":"10.1016/j.oraloncology.2024.107104","DOIUrl":"10.1016/j.oraloncology.2024.107104","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the accuracy of ultrasound in the quantification of tumor thickness (TT) and depth of invasion (DOI) of oral potentially malignant disorders and oral squamous cell carcinoma.</div></div><div><h3>Materials and methods</h3><div>A systematic review search was conducted in PubMed, Scopus, and Web of Science to answer the PICO question: “What is the correlation and the mean difference between ultrasound and histopathological assessment of tumor thickness and depth of invasion in patients with oral squamous cell carcinoma and oral potentially malignant disorders? The risk of bias was assessed, meta-analysis and trial sequential analysis was conducted on the available quantitative data, followed by trial sequential analysis.</div></div><div><h3>Results</h3><div>Of 2089 results, 48 studies were considered suitable for inclusion.</div><div>Meta-analysis showed a low heterogeneity for tumor thickness mean difference (I<sup>2</sup> = 0.00 %) with an overall standardized mean difference (SMD) of 0.13 (95 % CI: −0.07 to 0.33, p = 0.214). Tumor thickness correlation showed high heterogeneity (I<sup>2</sup> = 93.41 %). For depth of invasion, the mean difference had moderate heterogeneity (I<sup>2</sup> = 8.98 %) with an overall SMD of 0.27 (95 % CI: 0.06 to 0.48, p = 0.013). However, correlation analysis showed moderate heterogeneity (I<sup>2</sup> = 56.22 %). Trial sequential analysis confirmed the tumor thickness results but indicated more studies are required for depth of invasion to meet the required information size.</div></div><div><h3>Conclusion</h3><div>There were no statistically significant differences between the results of ultrasound and histological examination, the clinical use of this device cannot yet be confirmed.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107104"},"PeriodicalIF":4.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-15DOI: 10.1016/j.oraloncology.2024.107107
Adrian von Witzleben , Ayla Grages , Jaya Thomas , Jasmin Ezić , Cornelia Brunner , Patrick J. Schuler , Johann M. Kraus , Hans A. Kestler , Julius M. Vahl , Johannes Doescher , Emma V. King , Christian H. Ottensmeier , Thomas K. Hoffmann , Simon Laban
Introduction
A substantial proportion of head and neck squamous cell carcinoma (HNSCC), particularly oropharyngeal squamous cell carcinoma (OPSCC), is associated with human papillomavirus (HPV), resulting in distinct molecular phenotypes. In this study, we investigated differential immune checkpoint molecule (ICM) expression by HPV status using RNA sequencing data to identify additional ICM targets that may complement anti-PD1 antibodies.
Material and methods
RNA sequencing was performed on 51 OPSCC cases and validated using the TCGA HNSCC dataset. Unsupervised clustering and differential gene expression analyses in R were conducted based on HPV status. Additionally, a published single-cell RNA sequencing (scRNA) dataset of tumor-infiltrating lymphocytes (TIL) and peripheral immune cells (PBMC) (GSE139324) was analyzed with a Seurat pipeline grouped by HPV status.
Results
Our study identified a significant upregulation of all examined ICM in HPV-positive OPSCC through bulk RNA sequencing, validated by the TCGA cohort. Unsupervised clustering revealed a strong association between HPV-positive/-negative and high/low ICM expression cases respectively, indicating overlap between ICM and HPV status. In scRNA analysis, CD27, PD-1, OX-40, and BTLA were significantly more highly expressed on TILs of HPV-positive OPSCC. Conversely, VSIR was increased in PBMC and TILs of HPV-negative OPSCC, while LAG3 expression on PBMC was reduced in HPV-negative OPSCC.
Conclusion
Our study unveils the intricate interplay of ICMs in OPSCC, emphasizing the necessity for personalized therapeutic approaches based on HPV status and immune profiles. The identified ICMs, including PD1, CD27, and CTLA4, are promising candidates for further investigation and may enhance immunotherapeutic interventions in the HPV-dependent treatment strategies for OPSCC.
{"title":"Immune checkpoint expression on tumor-infiltrating lymphocytes (TIL) is dependent on HPV status in oropharyngeal carcinoma (OPSCC) – A single-cell RNA sequencing analysis","authors":"Adrian von Witzleben , Ayla Grages , Jaya Thomas , Jasmin Ezić , Cornelia Brunner , Patrick J. Schuler , Johann M. Kraus , Hans A. Kestler , Julius M. Vahl , Johannes Doescher , Emma V. King , Christian H. Ottensmeier , Thomas K. Hoffmann , Simon Laban","doi":"10.1016/j.oraloncology.2024.107107","DOIUrl":"10.1016/j.oraloncology.2024.107107","url":null,"abstract":"<div><h3>Introduction</h3><div>A substantial proportion of head and neck squamous cell carcinoma (HNSCC), particularly oropharyngeal squamous cell carcinoma (OPSCC), is associated with human papillomavirus (HPV), resulting in distinct molecular phenotypes. In this study, we investigated differential immune checkpoint molecule (ICM) expression by HPV status using RNA sequencing data to identify additional ICM targets that may complement anti-PD1 antibodies.</div></div><div><h3>Material and methods</h3><div>RNA sequencing was performed on 51 OPSCC cases and validated using the TCGA HNSCC dataset. Unsupervised clustering and differential gene expression analyses in R were conducted based on HPV status. Additionally, a published single-cell RNA sequencing (scRNA) dataset of tumor-infiltrating lymphocytes (TIL) and peripheral immune cells (PBMC) (GSE139324) was analyzed with a Seurat pipeline grouped by HPV status.</div></div><div><h3>Results</h3><div>Our study identified a significant upregulation of all examined ICM in HPV-positive OPSCC through bulk RNA sequencing, validated by the TCGA cohort. Unsupervised clustering revealed a strong association between HPV-positive/-negative and high/low ICM expression cases respectively, indicating overlap between ICM and HPV status. In scRNA analysis, CD27, PD-1, OX-40, and BTLA were significantly more highly expressed on TILs of HPV-positive OPSCC. Conversely, VSIR was increased in PBMC and TILs of HPV-negative OPSCC, while LAG3 expression on PBMC was reduced in HPV-negative OPSCC.</div></div><div><h3>Conclusion</h3><div>Our study unveils the intricate interplay of ICMs in OPSCC, emphasizing the necessity for personalized therapeutic approaches based on HPV status and immune profiles. The identified ICMs, including PD1, CD27, and CTLA4, are promising candidates for further investigation and may enhance immunotherapeutic interventions in the HPV-dependent treatment strategies for OPSCC.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107107"},"PeriodicalIF":4.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-15DOI: 10.1016/j.oraloncology.2024.107108
Elizabeth Gensterblum-Miller , Apurva Bhangale , Dana Al Majid , Victor Murcia Pienkowski , Malgorzata Rydzanicz , Joanna Janiszewska , Magdalena Kostrzewska-Poczekaj , Clifford Chang , Collin Brummel , Nicole L. Michmerhuizen , Jiayu Wang , Erin Sandford , Muneesh Tewari , Malgorzata Wierzbicka , Andrew C. Birkeland , Jonathan B. McHugh , Matthew E. Spector , Maciej Giefing , Malgorzata Jarmuz-Szymczak , Molly E. Heft Neal , J. Chad Brenner
Mucoepidermoid Carcinoma (MEC) is a common salivary malignant neoplasm. Approximately 60 % of MECs harbor translocations between CRTC1 or CRTC3 and MAML2, which are thought to drive disease pathogenesis. However, the precise structural mechanism driving this rearrangement remains uncharacterized. Here, we performed multi-omic and long read genomic sequencing, discovering a chain of alterations that created the CRTC1::MAML2 fusion, but also an unexpected MAML2 to MYBL1 rearrangement, suggesting that MYBL1 may play a larger role in salivary gland cancers than previously recognized. Furthermore, we discovered and validated recurrent TERT rearrangements and amplifications in MEC models. 5/5 MEC cell lines and 36/39 (92 %) primary MEC tumors harbored a TERT rearrangement or copy number amplification. Custom sequencing of the TERT locus confirmed translocation breakpoints in 13/33 (39 %) MECs, while exome sequencing confirmed frequent TERT amplifications. Critically, TERT knockdown in NCI-H292, a cell line with TERT promoter rearrangement, reduced clonogenic cell survival, supporting a critical role of this gene in MEC tumorigenesis. Overall, our data suggest that complex chromothripsis rearrangement mechanisms drive the formation of structural variation in CRTC1::MAML2 fusion positive and negative tumors and reveal highly recurrent structural variation driving TERT rearrangement in MEC.
{"title":"Long read sequencing identifies complex structural variant landscape and recurrent TERT rearrangements in mucoepidermoid carcinoma","authors":"Elizabeth Gensterblum-Miller , Apurva Bhangale , Dana Al Majid , Victor Murcia Pienkowski , Malgorzata Rydzanicz , Joanna Janiszewska , Magdalena Kostrzewska-Poczekaj , Clifford Chang , Collin Brummel , Nicole L. Michmerhuizen , Jiayu Wang , Erin Sandford , Muneesh Tewari , Malgorzata Wierzbicka , Andrew C. Birkeland , Jonathan B. McHugh , Matthew E. Spector , Maciej Giefing , Malgorzata Jarmuz-Szymczak , Molly E. Heft Neal , J. Chad Brenner","doi":"10.1016/j.oraloncology.2024.107108","DOIUrl":"10.1016/j.oraloncology.2024.107108","url":null,"abstract":"<div><div>Mucoepidermoid Carcinoma (MEC) is a common salivary malignant neoplasm. Approximately 60 % of MECs harbor translocations between <em>CRTC1</em> or <em>CRTC3</em> and <em>MAML2</em>, which are thought to drive disease pathogenesis. However, the precise structural mechanism driving this rearrangement remains uncharacterized. Here, we performed multi-omic and long read genomic sequencing, discovering a chain of alterations that created the <em>CRTC1::MAML2</em> fusion, but also an unexpected <em>MAML2</em> to <em>MYBL1</em> rearrangement, suggesting that <em>MYBL1</em> may play a larger role in salivary gland cancers than previously recognized. Furthermore, we discovered and validated recurrent <em>TERT</em> rearrangements and amplifications in MEC models. 5/5 MEC cell lines and 36/39 (92 %) primary MEC tumors harbored a <em>TERT</em> rearrangement or copy number amplification. Custom sequencing of the <em>TERT</em> locus confirmed translocation breakpoints in 13/33 (39 %) MECs, while exome sequencing confirmed frequent <em>TERT</em> amplifications. Critically, <em>TERT</em> knockdown in NCI-H292, a cell line with <em>TERT</em> promoter rearrangement, reduced clonogenic cell survival, supporting a critical role of this gene in MEC tumorigenesis. Overall, our data suggest that complex chromothripsis rearrangement mechanisms drive the formation of structural variation in <em>CRTC1::MAML2</em> fusion positive and negative tumors and reveal highly recurrent structural variation driving <em>TERT</em> rearrangement in MEC.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107108"},"PeriodicalIF":4.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1016/j.oraloncology.2024.107094
Shuai Li , TingTing Zhao , NengMing Liu , YueTao Li , HaiMei Chen , Chan Tang , Yi Wei , HaoYu Lu , XuanPing Huang
Objective
Oral cancer refers to a group of malignancies. The disease’s complexity requires a multidisciplinary approach, encompassing oncology, dentistry, epidemiology, molecular biology, and other fields. Given this multifaceted nature, bibliometrics has emerged as a crucial tool to navigate the vast array of academic literature surrounding oral cancer.
Method
82 highly cited publications on oral cancer were collected based on the Web of Science Core Collection. For bibliometric visualization and analysis, VOSviewer and R software (4.3.0 version) were used to explore publication trends, collaboration networks, core journals, research hotspots and authors in the field of oral cancer.
Results
This study analyzed 82 publications published over the past 11 years, including 46 published in the United States, 17 in China, 17 in UK, 12 in Canada and 10 in India. Quynh-Thu Le had the most publications (4 publications). Burtness B was the most cited author with 1,926 citations. University of Texas MD Anderson Cancer Center was the most active institution by contributing 7 publications. The most productive journal was journal of clinical oncology. Cluster Analysis of Co-occurrence Keywords revealed that top 10 highest number of core words were squamous-cell carcinoma, cancer, human-papillomavirus, survival, united-states, oropharyngeal cancer, risk, epidemiology, head and risk-factors.
Conclusion
Over the past 11 years, studies of oral cancer are increasingly. This bibliometric study may aid researchers in the understanding of the knowledge base and research frontiers associated with oral cancer. Emerging hotspots for research can be used as the subjects of future studies.
{"title":"Global research on oral cancer: A bibliometric analysis based on 82 highly cited publications from 2014 to 2024","authors":"Shuai Li , TingTing Zhao , NengMing Liu , YueTao Li , HaiMei Chen , Chan Tang , Yi Wei , HaoYu Lu , XuanPing Huang","doi":"10.1016/j.oraloncology.2024.107094","DOIUrl":"10.1016/j.oraloncology.2024.107094","url":null,"abstract":"<div><h3>Objective</h3><div>Oral cancer refers to a group of malignancies. The disease’s complexity requires a multidisciplinary approach, encompassing oncology, dentistry, epidemiology, molecular biology, and other fields. Given this multifaceted nature, bibliometrics has emerged as a crucial tool to navigate the vast array of academic literature surrounding oral cancer.</div></div><div><h3>Method</h3><div>82 highly cited publications on oral cancer were collected based on the Web of Science Core Collection. For bibliometric visualization and analysis, VOSviewer and R software (4.3.0 version) were used to explore publication trends, collaboration networks, core journals, research hotspots and authors in the field of oral cancer.</div></div><div><h3>Results</h3><div>This study analyzed 82 publications published over the past 11 years, including 46 published in the United States, 17 in China, 17 in UK, 12 in Canada and 10 in India. Quynh-Thu Le had the most publications (4 publications). Burtness B was the most cited author with 1,926 citations. University of Texas MD Anderson Cancer Center was the most active institution by contributing 7 publications. The most productive journal was journal of clinical oncology. Cluster Analysis of Co-occurrence Keywords revealed that top 10 highest number of core words were squamous-cell carcinoma, cancer, human-papillomavirus, survival, united-states, oropharyngeal cancer, risk, epidemiology, head and risk-factors.</div></div><div><h3>Conclusion</h3><div>Over the past 11 years, studies of oral cancer are increasingly. This bibliometric study may aid researchers in the understanding of the knowledge base and research frontiers associated with oral cancer. Emerging hotspots for research can be used as the subjects of future studies.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107094"},"PeriodicalIF":4.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.oraloncology.2024.107105
Bowen Yang , Xiaobo Dai , Zhixin Li, Zhenxin Wu, Shuai Chen, Chunjie Li, Bing Yan
Background
Head and neck squamous cell carcinoma poses a formidable treatment challenge owing to its complex anatomy and essential functions of the organs involved. Neoadjuvant immunotherapies, particularly PD-1 inhibitors, have shown promise in improving patient outcomes. Nevertheless, the ability to accurately predict which patients will benefit from neoadjuvant immunotherapy continues to be a significant hurdle.
Methods
We investigated 46 patients diagnosed with head and neck squamous cell carcinoma. Combined positive score was assessed before treatment. Serum samples were collected both before and after neoadjuvant immunotherapy, and subsequently analyzed utilizing surface-enhanced Raman spectroscopy.
Results
Significant differences in Raman spectral peaks were observed between the partial response and stable disease groups before treatment, particularly in the regions of 516–525 cm−1, 1240–1400 cm−1, 1600–1636 cm−1, and 1647–1680 cm−1. These peaks represent different cancer-related biochemical components, including protein and nucleic acid vibrations, disulfide bonds, amide III bands, CH2/CH3 deformations, and amide I bands. Principal Component Analysis-Linear Discriminant Analysis and Receiver Operating Characteristic analysis demonstrated that surface-enhanced Raman spectroscopy exhibited remarkable sensitivity and specificity, surpassing the combined positive score in assessing patient responses to neoadjuvant immunotherapy.
Conclusion
Surface-enhanced Raman spectroscopy offers significant potential to surpass the conventional combined positive score in predicting responses to neoadjuvant immunotherapy.
背景：头颈部鳞状细胞癌由于其复杂的解剖结构和相关器官的重要功能，给治疗带来了巨大挑战。新辅助免疫疗法，尤其是 PD-1 抑制剂，已显示出改善患者预后的前景。然而，准确预测哪些患者将从新辅助免疫疗法中获益仍然是一个重大障碍：方法：我们调查了 46 名确诊为头颈部鳞状细胞癌的患者。治疗前对综合阳性评分进行评估。在新辅助免疫疗法前后采集血清样本，随后利用表面增强拉曼光谱进行分析：结果：部分反应组和病情稳定组在治疗前的拉曼光谱峰值存在显著差异，尤其是在 516-525 cm-1、1240-1400 cm-1、1600-1636 cm-1 和 1647-1680 cm-1 区域。这些峰代表不同的癌症相关生化成分，包括蛋白质和核酸振动、二硫键、酰胺 III 带、CH2/CH3 变形和酰胺 I 带。主成分分析-线性判别分析和接收者操作特征分析表明，表面增强拉曼光谱在评估患者对新辅助免疫疗法的反应方面具有显著的灵敏度和特异性，超过了综合阳性评分：结论：表面增强拉曼光谱在预测新辅助免疫疗法反应方面具有超越传统综合阳性评分的巨大潜力。
{"title":"Noninvasive surface-enhanced Raman spectroscopy outperforms combined positive score in predicting sensitivity to neoadjuvant immunotherapy in head and neck squamous cell carcinoma","authors":"Bowen Yang , Xiaobo Dai , Zhixin Li, Zhenxin Wu, Shuai Chen, Chunjie Li, Bing Yan","doi":"10.1016/j.oraloncology.2024.107105","DOIUrl":"10.1016/j.oraloncology.2024.107105","url":null,"abstract":"<div><h3>Background</h3><div>Head and neck squamous cell carcinoma poses a formidable treatment challenge owing to its complex anatomy and essential functions of the organs involved. Neoadjuvant immunotherapies, particularly PD-1 inhibitors, have shown promise in improving patient outcomes. Nevertheless, the ability to accurately predict which patients will benefit from neoadjuvant immunotherapy continues to be a significant hurdle.</div></div><div><h3>Methods</h3><div>We investigated 46 patients diagnosed with head and neck squamous cell carcinoma. Combined positive score was assessed before treatment. Serum samples were collected both before and after neoadjuvant immunotherapy, and subsequently analyzed utilizing surface-enhanced Raman spectroscopy.</div></div><div><h3>Results</h3><div>Significant differences in Raman spectral peaks were observed between the partial response and stable disease groups before treatment, particularly in the regions of 516–525 cm<sup>−1</sup>, 1240–1400 cm<sup>−1</sup>, 1600–1636 cm<sup>−1</sup>, and 1647–1680 cm<sup>−1</sup>. These peaks represent different cancer-related biochemical components, including protein and nucleic acid vibrations, disulfide bonds, amide III bands, CH2/CH3 deformations, and amide I bands. Principal Component Analysis-Linear Discriminant Analysis and Receiver Operating Characteristic analysis demonstrated that surface-enhanced Raman spectroscopy exhibited remarkable sensitivity and specificity, surpassing the combined positive score in assessing patient responses to neoadjuvant immunotherapy.</div></div><div><h3>Conclusion</h3><div>Surface-enhanced Raman spectroscopy offers significant potential to surpass the conventional combined positive score in predicting responses to neoadjuvant immunotherapy.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107105"},"PeriodicalIF":4.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.oraloncology.2024.107103
R. Mishra , A. Kapur , VP. Mathur , D. Sardana
Background
The purpose of the present systematic review and meta-analyses was to appraise the case-control studies that have evaluated late adverse effects of chemotherapy for treating hematological malignancies in pediatric patients.
Methods
Five electronic databases along with grey literature were searched using broad keywords and MeSH terms for the articles that could meet the eligibility criteria. The Newcastle-Ottawa Scale was employed for quality assessment. DerSimonian and Laird random effects model using the (Restricted Maximum Likelihood) REML approach was used for meta-analyses to calculate the pooled Odds Ratios (ORs) for binary outcomes and Standardized Mean Difference (SMD) for continuous outcomes. The GRADE approach was used to synthesize the certainty of evidence utilizing GRADEpro® GDT software.
Results
8,052 records were obtained from the searches. After duplicate removal and initial screening of titles and abstracts, 109 articles were subjected to full-text reading but only 5 could be included. The pooled ORs of having root malformation, microdontia, tooth agenesis, taurodontism, and enamel defects in patients who have undergone treatment were 7.68, 5.39, 3.74, 2.00, and 1.84 compared to controls, respectively. The SMD for dental caries was also significant among the groups (p= 0.03) and indicated an SMD of 0.27 (95% CI: 0.03, 0.51) indicating higher pooled mean DMFT in the cases than controls.
Conclusions
Root malformations are associated with treatment for childhood hematological cancers with a moderate certainty of assessment. Tooth agenesis and microdontia are associated with low certainty of evidence, while taurodontism, enamel defects, and caries were associated with very low certainty of evidence. Future studies on larger sample sizes are needed to validate the findings as the number of studies included in our review was small.
{"title":"Late oral adverse effects of chemotherapy for hematological malignancies in children: A systematic review and meta-analysis of case-control studies","authors":"R. Mishra , A. Kapur , VP. Mathur , D. Sardana","doi":"10.1016/j.oraloncology.2024.107103","DOIUrl":"10.1016/j.oraloncology.2024.107103","url":null,"abstract":"<div><h3>Background</h3><div>The purpose of the present systematic review and meta-analyses was to appraise the case-control studies that have evaluated late adverse effects of chemotherapy for treating hematological malignancies in pediatric patients.</div></div><div><h3>Methods</h3><div>Five electronic databases along with grey literature were searched using broad keywords and MeSH terms for the articles that could meet the eligibility criteria. The Newcastle-Ottawa Scale was employed for quality assessment. DerSimonian and Laird random effects model using the (Restricted Maximum Likelihood) REML approach was used for meta-analyses to calculate the pooled Odds Ratios (ORs) for binary outcomes and Standardized Mean Difference (SMD) for continuous outcomes. The GRADE approach was used to synthesize the certainty of evidence utilizing GRADEpro® GDT software.</div></div><div><h3>Results</h3><div>8,052 records were obtained from the searches. After duplicate removal and initial screening of titles and abstracts, 109 articles were subjected to full-text reading but only 5 could be included. The pooled ORs of having root malformation, microdontia, tooth agenesis, taurodontism, and enamel defects in patients who have undergone treatment were 7.68, 5.39, 3.74, 2.00, and 1.84 compared to controls, respectively. The SMD for dental caries was also significant among the groups (p= 0.03) and indicated an SMD of 0.27 (95% CI: 0.03, 0.51) indicating higher pooled mean DMFT in the cases than controls.</div></div><div><h3>Conclusions</h3><div>Root malformations are associated with treatment for childhood hematological cancers with a moderate certainty of assessment. Tooth agenesis and microdontia are associated with low certainty of evidence, while taurodontism, enamel defects, and caries were associated with very low certainty of evidence. Future studies on larger sample sizes are needed to validate the findings as the number of studies included in our review was small.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107103"},"PeriodicalIF":4.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-11DOI: 10.1016/j.oraloncology.2024.107086
Gayathri Rengasamy, Vishnu Priya Veeraraghavan
{"title":"Using salivary DNA methylation to predict aging, cell changes, and protein levels for assessing oral mucositis severity and survival in head and neck cancer patients","authors":"Gayathri Rengasamy, Vishnu Priya Veeraraghavan","doi":"10.1016/j.oraloncology.2024.107086","DOIUrl":"10.1016/j.oraloncology.2024.107086","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107086"},"PeriodicalIF":4.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-09DOI: 10.1016/j.oraloncology.2024.107101
Yi-Chan Lee , Li-Jen Hsin , Wan-Ni Lin , Tuan-Jen Fang , Yao-Te Tsai , Ming-Shao Tsai , Cheng-Ming Luo , Shih-Wei Yang
Background
Advances in technology have enabled neck dissection techniques that reduce aesthetic impact while maintaining oncological safety. This study compares perioperative outcomes between robotic neck dissection via retroauricular/modified facelift incision (RNDRM) and conventional neck dissection via anterolateral cervical incision (CND).
Methods
Studies were selected from PubMed, Embase, and Cochrane Library. Data from studies comparing RNDRM and CND were extracted and analyzed using a random-effects model.
Results
The meta-analysis included eight studies with 421 cases. The RNDRM group had a longer operative time (mean difference [MD], 69.11; 95 % confidence interval [CI] 37.92 to 100.30) and higher cosmetic satisfaction (MD, 2.03; 95 % CI, 1.48 to 2.57), along with a higher risk of marginal mandibular nerve injury (risk difference [RD], 0.08; 95 % CI 0.01 to 0.15). No significant differences were found in operative blood loss (MD, 15.35; 95 % CI − 7.39 to 38.10), days of drain placement (MD, 0.49; 95 % CI, −0.02 to 1.00), drainage volume (MD, 15.29; 95 % CI, −45.22 to 75.79), overall lymph node yield (MD, −1.09; 95 % CI, −3.18 to 1.00), positive lymph node yield (MD, −0.61; 95 % CI, −2.20 to 0.98), length of hospital stay (MD, 1.07; 95 % CI −0.06 to 2.20), or regional recurrence (RD, 0.00; 95 % CI −0.05 to 0.05), with similar rates of other complications.
Conclusion
RNDRM offers better cosmetic outcomes but requires longer operative time and has a higher risk of marginal mandibular nerve injury than CND. It may be an alternative for selected patients, with surgery choice needing discussion between patient and surgeon.
{"title":"Robot-assisted versus conventional neck dissection in head and neck cancers: A systematic review and meta-analysis","authors":"Yi-Chan Lee , Li-Jen Hsin , Wan-Ni Lin , Tuan-Jen Fang , Yao-Te Tsai , Ming-Shao Tsai , Cheng-Ming Luo , Shih-Wei Yang","doi":"10.1016/j.oraloncology.2024.107101","DOIUrl":"10.1016/j.oraloncology.2024.107101","url":null,"abstract":"<div><h3>Background</h3><div>Advances in technology have enabled neck dissection techniques that reduce aesthetic impact while maintaining oncological safety. This study compares perioperative outcomes between robotic neck dissection via retroauricular/modified facelift incision (RNDRM) and conventional neck dissection via anterolateral cervical incision (CND).</div></div><div><h3>Methods</h3><div>Studies were selected from PubMed, Embase, and Cochrane Library. Data from studies comparing RNDRM and CND were extracted and analyzed using a random-effects model.</div></div><div><h3>Results</h3><div>The <em>meta</em>-analysis included eight studies with 421 cases. The RNDRM group had a longer operative time (mean difference [MD], 69.11; 95 % confidence interval [CI] 37.92 to 100.30) and higher cosmetic satisfaction (MD, 2.03; 95 % CI, 1.48 to 2.57), along with a higher risk of marginal mandibular nerve injury (risk difference [RD], 0.08; 95 % CI 0.01 to 0.15). No significant differences were found in operative blood loss (MD, 15.35; 95 % CI − 7.39 to 38.10), days of drain placement (MD, 0.49; 95 % CI, −0.02 to 1.00), drainage volume (MD, 15.29; 95 % CI, −45.22 to 75.79), overall lymph node yield (MD, −1.09; 95 % CI, −3.18 to 1.00), positive lymph node yield (MD, −0.61; 95 % CI, −2.20 to 0.98), length of hospital stay (MD, 1.07; 95 % CI −0.06 to 2.20), or regional recurrence (RD, 0.00; 95 % CI −0.05 to 0.05), with similar rates of other complications.</div></div><div><h3>Conclusion</h3><div>RNDRM offers better cosmetic outcomes but requires longer operative time and has a higher risk of marginal mandibular nerve injury than CND. It may be an alternative for selected patients, with surgery choice needing discussion between patient and surgeon.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"159 ","pages":"Article 107101"},"PeriodicalIF":4.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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