Oral oncology最新文献

{"title":"Commentary on, “Molecular features of T and N stage progression in laryngeal cancer.”","authors":"Gnanaprakash Jeyaraj","doi":"10.1016/j.oraloncology.2025.107331","DOIUrl":"10.1016/j.oraloncology.2025.107331","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"165 ","pages":"Article 107331"},"PeriodicalIF":4.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tongue tumor and prognostic factors: Could a diagnostic procedure influence patient outcomes?","authors":"Marta Tagliabue ,&nbsp;Rita De Berardinis ,&nbsp;Giulia Doi ,&nbsp;Francesco Chu ,&nbsp;Jessica Mellia ,&nbsp;Alberto Luchena ,&nbsp;Fausto Maffini ,&nbsp;Roberto Bruschini ,&nbsp;Stefano Zorzi ,&nbsp;Gioacchino Giugliano ,&nbsp;Stefano Riccio ,&nbsp;Sara Gandini ,&nbsp;Susanna Chiocca ,&nbsp;Mohssen Ansarin","doi":"10.1016/j.oraloncology.2025.107298","DOIUrl":"10.1016/j.oraloncology.2025.107298","url":null,"abstract":"<div><h3>Objectives</h3><div>Diagnosis of tongue tumors is often performed in primary care centers with an incisional biopsy using stitches in the lesion at the end of the procedure. We hypothesize that stitches placed in tumor tissue could potentially increase local inflammation and significantly affect the tumor microenvironment, influencing the cancer spread and local relapses.</div></div><div><h3>Materials and methods</h3><div>We conducted a retrospective study involving a consecutive series of 299 patients with Oral Tongue Squamous Cell Carcinoma (OTSCC). The study population was divided into two groups: Group 1 consisting of patients who did not receive stitches during the biopsy and, Group 2 composed by patients who had stitches placed in the tumor at the time of diagnosis. All data collected were statistically analyzed.</div></div><div><h3>Results</h3><div>The use of stitches during biopsy was associated with a negative prognostic role in Disease Free Survival (DFS), Disease Specific Survival (DSS) and a worsening trend in cause specific overall survival (cs-OS) for early stages (I-II) OTSCC. This negative prognostic impact was confirmed in the cumulative multivariable analyses of the DFS and DSS curves for stages I-II. The negative prognostic impact was not observed for patients with advanced-stage carcinoma and for OS.</div></div><div><h3>Conclusion</h3><div>Our analysis suggested that the placement of stitches during biopsy in patients with early OTSCC may worsen outcomes in terms of DFS and DSS. We recommend evaluating whether stitches are truly necessary during biopsy or if they could be avoided altogether by using less invasive biopsy techniques.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"165 ","pages":"Article 107298"},"PeriodicalIF":4.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes following IMRT alone in head and neck squamous cell carcinoma ordinarily managed with concurrent chemo-radiotherapy","authors":"Marc Vincent N. Barcelona ,&nbsp;John Waldron ,&nbsp;Brian O’ Sullivan ,&nbsp;Jie Su ,&nbsp;Scott V. Bratman ,&nbsp;John Byoung Cho ,&nbsp;Ezra Hahn ,&nbsp;Andrew J. Hope ,&nbsp;Ali Hosni ,&nbsp;John Kim ,&nbsp;Andrew McPartlin ,&nbsp;Jolie Ringash ,&nbsp;Nauman Malik ,&nbsp;Lillian L. Siu ,&nbsp;Anna Spreafico ,&nbsp;Lawson Eng ,&nbsp;Enrique Sanz-Garcia ,&nbsp;Christopher Michael Kai-Lup Yao ,&nbsp;John de Almeida ,&nbsp;Li Tong ,&nbsp;Shao Hui Huang","doi":"10.1016/j.oraloncology.2025.107299","DOIUrl":"10.1016/j.oraloncology.2025.107299","url":null,"abstract":"<div><h3>Purpose/Objective(S)</h3><div>We report outcomes following IMRT-alone in patients with head-and-neck squamous cell carcinoma (HNSCC) ordinarily managed with concurrent chemo-radiotherapy.</div></div><div><h3>Materials/Methods</h3><div>HNSCC (excluding T1-2 N0) patients treated with IMRT-alone from 2005 to 2019 were included and restaged according to TNM-8. Overall survival (OS) was stratified by TNM-8 stage subgroups within HPV-positive (HPV + ) and separately within HPV-negative (HPV–) HNSCC. Multivariable analysis (MVA) identified prognostic factors for OS.</div></div><div><h3>Results</h3><div>A total of 460 patients with HPV + and 623 HPV– HNSCC were identified. Reasons for chemotherapy omission were: age &gt; 70 years and/or frailty (n = 551, 51 %), cisplatin contraindication (n = 241, 22 %), patient’ preference (n = 106, 10 %), and clinician’s decision (n = 185, 17 %). IMRT was delivered mostly using altered-fractionation: moderately-accelerated (70 Gy/35 fractions [f]/6 weeks [w], 55 %), hypofractionated (60 Gy/25f/5w, 14 %), and hyperfractionated-accelerated (64 Gy/40f/4w, 25 %). Median follow-up was 5.0 years. Five-year OS for HPV + stage-I-single node, stage-I-multiple nodes, stage-II-T1-2 N2, stage-II-T3 N0-N2, and stage-III were 90 %, 79 %%, 80 %, 64 %, and 33 %, and for HPV– stage III, IVA, and IVB were 47 %, 27 %, and 13 %, respectively. MVA confirmed lower OS in HPV + stage-I-multiple nodes (p = 0.03), II-T3 N0-N2 and III (vs stage-I-single node) and HPV– stage IVA/IVB (vs III) (p &lt; 0.01), and marginally lower OS in HPV + stage-II-T3 N0-2 (vs I-single node) (p = 0.07).</div></div><div><h3>Conclusion</h3><div>Altered fractionated IMRT-alone is a valid option for patients with HPV + stage I-single node HNSCC, and an acceptable alternative for elderly/frail or cisplatin ineligible patients with HPV + stage I-multiple nodes and T1-2 N2 HNSCC. Patients with HPV + T3-T4 or N3 and HPV– stage III/IV HNSCC had unsatisfactory OS, requiring further research into alternative options.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"165 ","pages":"Article 107299"},"PeriodicalIF":4.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on, “Factors associated with detection of oligometastatic recurrence and outcome following definitive (chemo)radiotherapy for oropharyngeal carcinoma.”","authors":"Gnanaprakash Jeyaraj","doi":"10.1016/j.oraloncology.2025.107332","DOIUrl":"10.1016/j.oraloncology.2025.107332","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"165 ","pages":"Article 107332"},"PeriodicalIF":4.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment outcomes of sinonasal adenoid cystic carcinoma: a single-center experience","authors":"Hye-Bin Jang,&nbsp;Dong Hoon Lee,&nbsp;Sang Chul Lim","doi":"10.1016/j.oraloncology.2025.107317","DOIUrl":"10.1016/j.oraloncology.2025.107317","url":null,"abstract":"<div><h3>Objective</h3><div>Sinonasal adenoid cystic carcinoma (ACC) is a rare malignancy characterized by perineural invasion and a high risk of late recurrence. This study examines the clinical characteristics and treatment outcomes of patients with sinonasal ACC treated at a single institution over 15 years.</div></div><div><h3>Patients and methods</h3><div>A retrospective analysis was conducted on 19 patients with histologically confirmed sinonasal ACC treated at Chonnam National University Hwasun Hospital from 2010 to 2024.</div></div><div><h3>Results</h3><div>Nasal obstruction was the most common presenting symptom (57.8 %), followed by facial pain and numbness (21.0 %) and epistaxis (10.5 %). The maxillary sinus was the most frequently affected site (52.6 %). At initial diagnosis, regional lymph node and distant metastases were each observed in one patient. Most cases were diagnosed at stage IV (57.9 %), with perineural invasion detected in 31.6 % of cases. Among the 17 patients who completed treatment, surgery followed by radiotherapy was the predominant treatment modality (82.4 %). Two patients were deemed inoperable and received definitive chemoradiotherapy or best supportive care. Over a mean follow-up of 87.5 ± 60.2 months, 11 patients (64.7 %) experienced recurrence, with a mean time to recurrence of 52.8 ± 45.7 months. Survival analysis identified tumor stage as the only significant prognostic factor (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>Sinonasal ACC is frequently diagnosed at an advanced stage and demonstrates a high recurrence rate despite multimodal treatment. The tumor stage emerged as the strongest prognostic indicator of survival, highlighting the need for early detection and aggressive therapeutic interventions to improve patient outcomes.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"165 ","pages":"Article 107317"},"PeriodicalIF":4.0,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on, “Risk factors and a risk assessment model for venous thromboembolism in head and neck cancer surgery.”","authors":"Gnanaprakash Jeyara","doi":"10.1016/j.oraloncology.2025.107320","DOIUrl":"10.1016/j.oraloncology.2025.107320","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"165 ","pages":"Article 107320"},"PeriodicalIF":4.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143848564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a patient reported outcomes based machine learning model to predict recurrences in head and neck cancer","authors":"Christopher M.K.L. Yao ,&nbsp;Katrina Hueniken ,&nbsp;Shao Hui Huang ,&nbsp;Geoffrey Liu ,&nbsp;Scott Bratman ,&nbsp;Andrew Hope ,&nbsp;Andrew McPartlin ,&nbsp;Jillian C. Tsai ,&nbsp;Sharon Tzelnik ,&nbsp;David Goldstein ,&nbsp;Ali Hosni ,&nbsp;Timothy C.Y. Chan ,&nbsp;John R. de Almeida","doi":"10.1016/j.oraloncology.2025.107304","DOIUrl":"10.1016/j.oraloncology.2025.107304","url":null,"abstract":"<div><h3>Introduction</h3><div>Recurrence rates among Head and Neck Cancer (HNC) patients are high, with earlier detection associated with improved survival. Patient-reported outcomes (PROs) have increasingly been found to predict patient care needs. Here, we examine whether PROs specific to HNC patients or general can predict disease progression using Machine Learning (ML) algorithms.</div></div><div><h3>Methods</h3><div>This was an analysis of 1,302 HNC patients,<!--> <!-->including patients who completed at least one MD Anderson Symptom Inventory (MDASI) or Edmonton Symptom Assessment Score (ESAS) questionnaire 3 months following curative intent treatment. ML models, including least absolute shrinkage and selection operator (LASSO) logistic regression and Random Forest (RF) were applied to baseline or longitudinal PRO changes to predict recurrences. Predictive performances were assessed via area under the receiver-operating curve, computed with 10-fold cross-validation. Relative variable importance were computed with average decrease in out-of-bag prediction accuracy of each tree.</div></div><div><h3>Results</h3><div>Disease recurrence occurred in 9.5 % (n = 123) of HNC patients. Baseline post-treatment MDASI, RF models demonstrated an area under the curve (AUC) approximating 0.675, sensitivity of 0.83 and specificity of 0.58 with pain, speech, and dry mouth as key variables. When stratifying patients by HPV status, our non-HPV model based on pain, distress, and mood yielded an AUC of 0.71 at 3 months and 0.70 at 6 months.</div></div><div><h3>Conclusion</h3><div>ML models using HNC specific PROs can identify patients at high risk for disease progression with moderate accuracy. Prospective studies with larger dataset and further analysis are needed to refine these models and evaluate their potential in guiding post-treatment surveillance.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"165 ","pages":"Article 107304"},"PeriodicalIF":4.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant treatment in elderly patients undergoing transoral surgery for HPV-related oropharyngeal cancer","authors":"Andrea Costantino ,&nbsp;Claudio Sampieri ,&nbsp;Bruce H. Haughey ,&nbsp;Uthman Alamoudi ,&nbsp;Armando De Virgilio ,&nbsp;J. Scott Magnuson","doi":"10.1016/j.oraloncology.2025.107312","DOIUrl":"10.1016/j.oraloncology.2025.107312","url":null,"abstract":"<div><h3>Objectives</h3><div>Older adults are an increasing proportion of patients with HPV-related oropharyngeal squamous cell carcinoma (OPSCC), and transoral surgery (TOS) remains a valid treatment option for this population. This study aimed to evaluate the impact of adjuvant therapy on survival outcomes in this group.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed data from the National Cancer Database (NCDB) for older adults (≥65 years) diagnosed with OPSCC and treated with primary TOS. Patients were stratified into low, intermediate, and high-risk groups according to specific pathological criteria. The survival benefit of adjuvant therapy was assessed using a multivariable Cox regression model.</div></div><div><h3>Results</h3><div>A total of 998 patients undergoing primary TOS for HPV-related OPSCC were classified in low (N = 347, 34.8 %), intermediate (N = 261, 26.1 %) and high (N = 390, 39.1 %) risk groups. Adjuvant treatment showed no significant benefit in the low (adjusted HR: 0.70; 95 % CI: 0.33–1.47) and intermediate (HR: 0.73; 95 % CI: 0.36–1.48) risk groups. Adjuvant treatment was beneficial in the high risk group (adjusted HR: 0.40, 95 % CI: 0.25–0.62), with adjuvant chemoradiotherapy (adjusted HR: 0.28 95 % CI: 0.16–0.48; p &lt; 0.001) showing a slight advantage compared to radiotherapy alone (adjusted HR: 0.61, 95 % CI: 0.36–1.03).</div></div><div><h3>Conclusion</h3><div>The findings suggest that adjuvant therapy should be selectively applied in older adults with OPSCC, with a significant survival benefit observed primarily in high-risk patients. Future studies are needed to confirm the safety and efficacy of treatment de-escalation strategies in this population.</div></div>","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"165 ","pages":"Article 107312"},"PeriodicalIF":4.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on, “Rhabdomyosarcoma of head and neck varies in aggressiveness depending on the specific site of origin.”","authors":"Gnanaprakash Jeyaraj","doi":"10.1016/j.oraloncology.2025.107318","DOIUrl":"10.1016/j.oraloncology.2025.107318","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"165 ","pages":"Article 107318"},"PeriodicalIF":4.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An elderly man with tongue swelling and dysphagia","authors":"Jie Deng,&nbsp;Kexiong Ouyang,&nbsp;Chuandong Zhu","doi":"10.1016/j.oraloncology.2025.107313","DOIUrl":"10.1016/j.oraloncology.2025.107313","url":null,"abstract":"","PeriodicalId":19716,"journal":{"name":"Oral oncology","volume":"165 ","pages":"Article 107313"},"PeriodicalIF":4.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}