Establishment of Optimal Drug Delivery System and Evaluation of Utilization of Hydrogel Contact Lens According to the Addition Method of Tretinoin and Bovine Serum Albumin.
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Abstract
This study aims to build an optimal drug delivery system by manufacturing and evaluating a hydrogel contact lens using Tretinoin (ATRA) and protein nanoparticles to improve the drug delivery system as an ophthalmic medical contact lens. To evaluate the optical and physical properties of the manufactured lens, the spectral transmittance, refractive index, water content, contact angle, AFM, tensile strength, drug delivery, and antibacterial properties were analyzed. The contact lens was manufactured to contain ATRA and bovine serum albumin (BSA) in different ways, and the results confirmed that A, B, and C each had different physical properties. In particular, for Sample A, using the soak and release method and using ATRA solution in the contact lens with BSA added, the wettability was 55.94°, the tensile strength was 0.1491 kgf/mm2, and drug delivery released 130.35 μm over 336 h, which was found to be superior to samples B and C. Therefore, the three hydrogel contact lenses compared in this study according to the addition method of ATRA and BSA can be used in various ways to build an optimal drug delivery system that is very useful as an ophthalmic medical lens.
期刊介绍：
Polymers (ISSN 2073-4360) is an international, open access journal of polymer science. It publishes research papers, short communications and review papers. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Polymers provides an interdisciplinary forum for publishing papers which advance the fields of (i) polymerization methods, (ii) theory, simulation, and modeling, (iii) understanding of new physical phenomena, (iv) advances in characterization techniques, and (v) harnessing of self-assembly and biological strategies for producing complex multifunctional structures.
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