Synergistic photothermal and chemo-therapeutic platform utilizing Cu2-xSe/PDA/AIPH nanoparticles for targeted tumor eradication

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-04-01 Epub Date: 2025-01-19 DOI:10.1016/j.bioadv.2025.214196

Haoyan Cheng , Beng Ma , Wanting Xia , Ying Yu , Jiayi Li , Keke Zhang , Linlin Shi , Hao Hu , Shegan Gao , Zhihong Zhu

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Abstract

In this study, we developed an innovative Cu_2-xSe/PDA/AIPH nanoparticle platform that combines photothermal therapy and chemotherapy for effective tumor treatment. The Cu_2-xSe nanoparticles, known for their strong near-infrared (NIR) absorption, were encapsulated within a polydopamine (PDA) and 2,2′-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIPH) matrix. Upon NIR irradiation, the platform triggers localized heating and subsequent thermal decomposition of AIPH, releasing ROS to induce significant oxidative damage in tumor cells. In vitro and in vivo experiments demonstrated that Cu_2-xSe/PDA/AIPH nanoparticles exhibit excellent biocompatibility, effective photothermal conversion, and potent anticancer efficacy. This multifunctional nanosystem offers a promising approach for enhancing tumor therapy by combining PTT with ROS-mediated chemotherapy.

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利用Cu2-xSe/PDA/AIPH纳米颗粒靶向肿瘤根除的协同光热和化疗平台。

在这项研究中，我们开发了一种创新的Cu2-xSe/PDA/AIPH纳米颗粒平台，将光热疗法和化疗结合起来，有效治疗肿瘤。Cu2-xSe纳米颗粒具有较强的近红外（NIR）吸收，被封装在聚多巴胺（PDA）和2,2'-偶氮唑[2-（2-咪唑啉-2-基）丙烷]盐酸（AIPH）基质中。在近红外照射下，该平台触发AIPH的局部加热和随后的热分解，释放ROS，诱导肿瘤细胞明显的氧化损伤。体外和体内实验表明，Cu2-xSe/PDA/AIPH纳米颗粒具有良好的生物相容性、有效的光热转化和强大的抗癌功效。这种多功能纳米系统通过将PTT与ros介导的化疗相结合，为增强肿瘤治疗提供了一种有希望的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!