Novel nutrition strategies in gastric and esophageal cancer.

IF 3.8 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Expert Review of Gastroenterology & Hepatology Pub Date : 2025-01-26 DOI:10.1080/17474124.2025.2457444

Ellen Boyle, Jessie A Elliott

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Abstract

Introduction: Advances in treatment strategies for gastric and esophageal cancer have led to improved long-term outcomes, however the local and systemic effects of tumor growth, neoadjuvant therapies and surgery, results in specific nutritional challenges. Comprehensive nutritional evaluation and support represents a core component of multidisciplinary holistic care for this patient population.

Areas covered: This review provides a detailed overview of the nutritional challenges in gastric and esophageal cancer, with a focus on malignant obstruction, preoperative optimization and nutrition in survivorship. We discuss the current management options for these challenges, with an overview of the present evidence base, and detail the future therapeutic targets in nutritional support in gastric and esophageal cancer.

Expert opinion: The advent of bariatric surgery to treat obesity has yielded fascinating insights into the postoperative attenuation of gut hormone signaling that underpins early satiety and persistent weight loss following gastric and esophageal cancer surgery, providing new therapeutic targets. The management of malignant dysphagia and obstruction currently lacks robust evidence, particularly in patient reported outcomes, to support an optimal strategy. The advantages of nutritional optimization in the pre- and immediate postoperative phase are well documented, but the exact regimens to optimize patient outcomes and quality of life are not clear.

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来源期刊

Expert Review of Gastroenterology & Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

6.80

自引率

2.60%

发文量

审稿时长

6-12 weeks

期刊介绍： The enormous health and economic burden of gastrointestinal disease worldwide warrants a sharp focus on the etiology, epidemiology, prevention, diagnosis, treatment and development of new therapies. By the end of the last century we had seen enormous advances, both in technologies to visualize disease and in curative therapies in areas such as gastric ulcer, with the advent first of the H2-antagonists and then the proton pump inhibitors - clear examples of how advances in medicine can massively benefit the patient. Nevertheless, specialists face ongoing challenges from a wide array of diseases of diverse etiology.

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