{"title":"GBR assisted <i>in situ</i> Onlay bone grafting for the posterior maxillary horizontal ridge augmentation: a case report and literature review.","authors":"Mucong Li, Xiuyu Liu, Jing Zhou, Jiaqian You, Sheng Chen, Jian Feng, Xuyan Wei, Hanchi Wang, Yanmin Zhou","doi":"10.3389/fbioe.2024.1535207","DOIUrl":null,"url":null,"abstract":"<p><p>The posterior mandible is the primary area for occlusal function. However, long-term tooth loss in the posterior mandible often leads to rapid absorption of both buccal and lingual trabecular bone plates and subsequent atrophy of the alveolar ridge. This ultimately results in horizontal bone deficiencies that complicate achieving an optimal three-dimensional placement for dental implants. Conventional techniques employed clinically for horizontal bone augmentation have limited efficacy, cause significant surgical trauma, and require extended treatment duration. Consequently, the selection of an effective and minimally invasive bone augmentation technique for restoring bone width is an essential prerequisite for successful implant restoration in the posterior mandible. This clinical case study presented a treatment approach involving guided bone regeneration (GBR) and <i>in situ</i> Onlay grafting for bone level augmentation in the blade-shaped alveolar ridge of the posterior mandible, followed by implant restoration. By rotating the <i>in situ</i> sourced bone block, the denser bone volume at the base of the blade-shaped alveolar ridge was transferred to the crest of the alveolar ridge, obviating the necessity for a secondary operative site and mitigating complications such as pain, edema, sensory abnormalities, and nerve injury. Incorporation of trabecular bone within the recipient area enhanced fixation while augmenting vascular supply. A significant increase in bone volume by 1,628.21 mm<sup>3</sup> was achieved within 7 months postoperatively. Overall, this novel approach offers valuable insights into minimally invasive and stable techniques for alveolar bone augmentation.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"12 ","pages":"1535207"},"PeriodicalIF":4.3000,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757243/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Bioengineering and Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3389/fbioe.2024.1535207","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The posterior mandible is the primary area for occlusal function. However, long-term tooth loss in the posterior mandible often leads to rapid absorption of both buccal and lingual trabecular bone plates and subsequent atrophy of the alveolar ridge. This ultimately results in horizontal bone deficiencies that complicate achieving an optimal three-dimensional placement for dental implants. Conventional techniques employed clinically for horizontal bone augmentation have limited efficacy, cause significant surgical trauma, and require extended treatment duration. Consequently, the selection of an effective and minimally invasive bone augmentation technique for restoring bone width is an essential prerequisite for successful implant restoration in the posterior mandible. This clinical case study presented a treatment approach involving guided bone regeneration (GBR) and in situ Onlay grafting for bone level augmentation in the blade-shaped alveolar ridge of the posterior mandible, followed by implant restoration. By rotating the in situ sourced bone block, the denser bone volume at the base of the blade-shaped alveolar ridge was transferred to the crest of the alveolar ridge, obviating the necessity for a secondary operative site and mitigating complications such as pain, edema, sensory abnormalities, and nerve injury. Incorporation of trabecular bone within the recipient area enhanced fixation while augmenting vascular supply. A significant increase in bone volume by 1,628.21 mm3 was achieved within 7 months postoperatively. Overall, this novel approach offers valuable insights into minimally invasive and stable techniques for alveolar bone augmentation.
期刊介绍:
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.