The impact of diabetes and antidiabetics on uro-oncological disease outcomes: A single center experience.

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY Urologia Internationalis Pub Date : 2025-01-24 DOI:10.1159/000543757

Moustafa Elleisy, Heike Zettl, Desiree Louise Dräger, Oliver W Hakenberg

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引用次数: 0

Abstract

Introduction: To determine the impact of diabetes and antidiabetic medications on referral and pathological outcomes in uro-oncology cases. We report preliminary results from a single center study.

Methods: We retrospectively collected data from 781 patients treated between 2018 and 2023 for radical prostatectomy (RP) for prostate cancer (PCa), radical cystectomy (RC) for bladder cancer (BCa), radical nephroureterectomy (RNU) for upper tract urothelial carcinoma, partial nephrectomy (PN) and radical nephrectomy (RN) for renal cell cancer (RCC). A total of 617 (79%) patients were non-diabetics and 164 (21%) were diabetics. Patient data were assessed for differences between diabetics and non-diabetics.

Results: All diabetic patients had a significantly higher BMI than non-diabetic patients (p<0.05 for PCa and p=0.006 for RC respectively). In diabetic patients with PCa, a lower proportion of ISUP grade 3 and 5 PCa was seen (p=0.047). In diabetic RCC patients on anti-diabetic medication, there was a significantly higher incidence of recurrence rates after RN (p=0.015). Penile cancer was diagnosed in diabetic patients at an older age (p=0.019).

Conclusion: Significantly, higher BMI was observed for RP and RC in diabetic patients, as well as for RCC after RN. Diabetics showed a significantly higher occurrence of recurrence for RCC after RN.

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来源期刊

Urologia Internationalis 医学-泌尿学与肾脏学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

3-8 weeks

期刊介绍： Concise but fully substantiated international reports of clinically oriented research into science and current management of urogenital disorders form the nucleus of original as well as basic research papers. These are supplemented by up-to-date reviews by international experts on the state-of-the-art of key topics of clinical urological practice. Essential topics receiving regular coverage include the introduction of new techniques and instrumentation as well as the evaluation of new functional tests and diagnostic methods. Special attention is given to advances in surgical techniques and clinical oncology. The regular publication of selected case reports represents the great variation in urological disease and illustrates treatment solutions in singular cases.