Exploring the influence of PCB exposure on neonatal birth outcomes and neurobehavioral development after 15 years of prohibition

Abstract

Despite polychlorinated biphenyls (PCBs) have been banned in Taiwan for fifteen years, epidemiological studies indicated that prenatal PCB exposure may still affect newborns and their birth outcomes. The study aimed to investigate the association between PCB concentrations in umbilical cord blood and infants' birth outcomes and neurodevelopment. We recruited 100 pairs of mothers and infants, residing in Changhua and Yunlin countries in Taiwan from 2014 to 2016. Maternal questionnaire surveys conducted to collect demographic data, and the Chinese version of the Neonatal Neurobehavioral Assessment Scale was used to assess the development of their neurological behavior in newborns within one to two weeks after birth. Additionally, the Infant Temperament Questionnaire was used to evaluate newborns’ responses to stimuli. The measured levels of 23 PCB congeners were analyzed using gas chromatography-electron capture negative ionization quadrupole mass spectrometry (GC-NICI-qMS). Multiple regression explored correlations between prenatal PCB exposure and neonatal birth outcomes, neurobehavioral, and temperament. Additionally, we used the Weighted Quantile Sum (WQS) regression model analysis to identify the major contributing congener. The results revealed that 9 PCB congeners were commonly found in the study participants, specifically PCB138, PCB153, PCB180, PCB156, PCB170, PCB177, PCB187, PCB194, and PCB201. The top three PCBs congeners by levels were PCB138, PCB153, and PCB180 (17.28 ± 16.84, 11.50 ± 15.12, 8.09 ± 14.10 pg/g wet weight, respectively). The decrease in birth weight and head circumference in newborns were each associated with 7 different PCB congeners, with 6 of them being correlated with both, including PCB153, PCB156, PCB177, PCB180, PCB187, and PCB194. Specifically, PCB153 was associated with delayed neurobehavioral development in newborns. Exposure to PCB153, PCB177, and PCB180 influenced the temperament development of newborns. The WQS results indicated that PCB156 and PCB177 were the major contributors to decreased birth weight and head circumference. In conclusion, despite the prohibition of PCB usage, prenatal exposure to PCBs may still affect neonatal health. It is recommended that Taiwan should monitor local newborns' long-term PCB exposure and track potential adverse health effects in their future development.