Jianjun Hao, Lu Ren, Jingwen Tan, Yulin Peng, Lin-Hai Jing, Pan Han
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引用次数: 0
Abstract
Gem-difluoroethylene moiety holds pivotal roles in drug research owing to its unique ability as a bioisostere of the carbonyl group. Here, magnesium-mediated reductive defluorinative cross-electrophile coupling of α-trifluoromethyl styrene with carbon-centered electrophiles was developed. This method featured readily accessible reagents, mild conditions, and wide substrate scope, enabling the efficient production of gem-difluoroallyl carboxylic acid and ketones. The establishment of this protocol will offer a general alternative for the acquisition of gem-difluoroethylene compounds.
期刊介绍：
Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry.
The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.
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