Development and application of an efficient, accurate, and environmentally friendly liquid chromatography-tandem mass spectrometry method for the determination of five Alternaria toxins in wheat.

IF 8.2 1区农林科学 Q1 CHEMISTRY, APPLIED Food Chemistry: X Pub Date : 2025-01-07 eCollection Date: 2025-01-01 DOI:10.1016/j.fochx.2025.102167

Huiyuan Lang, Zengwang Guo, Yu Wu, Li Li, Hongmei Liu, Lianzhou Jiang, Songxue Wang, Jin Ye

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Abstract

The contamination of Alternaria toxins poses a potential risk to human health. This study developed a rapid, efficient, and environmentally friendly method for the simultaneous determination of five types of Alternaria toxins in wheat using high-precision and stable isotope liquid chromatography tandem mass spectrometry. The comparison between dilution method and solid-phase extraction method shows that the former achieves satisfactory results with a simple and convenient sample purification method. The quantitative limit range is 0.88 to 1.68 μg/kg. The recoveries are between 81.40% and 102.68%, with RSD less than 11.95%. The method was used to analyze 60 samples from the main wheat producing areas in China. The results showed that Tenuzonic acid had the highest detection rate (100%), followed by Tentoxin (95%), Alternariol (66.67%), and Alternariol monomethyl ether (53.33%). There is a certain pollution risk that needs to be taken seriously and monitoring should be strengthened.

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高效、准确、环保的液相色谱-串联质谱法测定小麦中5种稻瘟菌毒素的研究

交替孢毒素的污染对人类健康构成潜在风险。本研究建立了一种快速、高效、环保的同时测定小麦中5种稻瘟菌毒素的高精度、稳定同位素液相色谱串联质谱法。稀释法与固相萃取法的比较表明，稀释法具有简单方便的样品纯化方法，取得了满意的结果。限量范围为0.88 ~ 1.68 μg/kg。加样回收率在81.40% ~ 102.68%之间，RSD < 11.95%。采用该方法对中国小麦主产区的60份样品进行了分析。结果表明，天冬氨酸的检出率最高（100%），其次为天冬毒素（95%）、Alternariol（66.67%）和Alternariol单甲醚（53.33%）。存在一定的污染风险，需要重视和加强监测。

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来源期刊

Food Chemistry: X CHEMISTRY, APPLIED-

CiteScore

4.90

自引率

6.60%

发文量

315

审稿时长

55 days

期刊介绍： Food Chemistry: X, one of three Open Access companion journals to Food Chemistry, follows the same aims, scope, and peer-review process. It focuses on papers advancing food and biochemistry or analytical methods, prioritizing research novelty. Manuscript evaluation considers novelty, scientific rigor, field advancement, and reader interest. Excluded are studies on food molecular sciences or disease cure/prevention. Topics include food component chemistry, bioactives, processing effects, additives, contaminants, and analytical methods. The journal welcome Analytical Papers addressing food microbiology, sensory aspects, and more, emphasizing new methods with robust validation and applicability to diverse foods or regions.