Blood monocyte fraction and computed tomography attenuation value of bone marrow in fever of unknown origin: A retrospective analysis for differentiating adult-onset Still's disease and intravascular large B-cell lymphoma.
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Abstract
Objectives: To investigate the factors affecting laboratory data and computed tomography (CT) attenuation values of L1 trabecular and femoral bone marrow, potential markers for differentiating between adult-onset Still's disease and intravascular large B-cell lymphoma.
Methods: We conducted a retrospective observational study on patients diagnosed with adult-onset Still's disease or intravascular large B-cell lymphoma. Clinical and laboratory data, and CT attenuation values of the bone marrow were compared. An exploratory analysis was conducted to identify factors useful for discriminating between the two groups.
Results: 30 patients with adult-onset Still's disease and 14 with intravascular large B-cell lymphoma were included; among them, 17 and 14 patients, respectively, underwent plain CT. No significant differences in CT attenuation values were noted; however, significant differences in various clinical and laboratory data, including neutrophil counts and soluble interleukin 2 receptor levels, were observed. Exploratory analysis of the monocyte fraction, guided by previous reports, suggested a cutoff of ≥ 9.65% for intravascular large B-cell lymphoma, with a sensitivity of 64.3% and specificity of 96.7%.
Conclusion: This study suggests that, besides neutrophil counts and soluble interleukin 2 receptor levels, monocyte fractionation is a useful differentiation criterion between adult-onset Still's disease and intravascular large B-cell lymphoma.
期刊介绍：
Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery.
Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered.
Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions
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