Effectiveness of text message reminder and motivational interview on adherence to methadone treatment in Vietnam: a randomized controlled trial.

Uyen Thanh Nu Le, Thuan Thien Tran, Giang Truong Le, Ha Khanh Mai Huynh, Han Hy Thi Bui, Phuong Thu Thi Pham, Mai Ngoc Thi Nguyen, Truc Thanh Thai
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Abstract

Background: Methadone maintenance treatment (MMT) is effective for treating opioid dependence. However, nonadherence can increase the risk of withdrawal syndrome, relapse, and overdose.

Methods: A community-based randomized controlled trial was conducted on 450 opioid-dependent patients undergoing MMT at three clinics in Ho Chi Minh City, Vietnam. Patients were randomly allocated into three groups including control, text message reminder (TMR), and motivational interview (MI). Treatment adherence was assessed every 3 months, including complete adherence, consecutive adherence, and weekend adherence.

Results: After 6 months, the MI group had significantly higher complete adherence than the control group (RR = 1.36, 95% CI: 1.09-1.69). The TMR group showed higher complete adherence at 3 months (RR = 1.27, 95% CI: 1.02-1.58) and 6 months (RR = 1.28, 95% CI: 1.06-1.56) compared to the control group. Weekend adherence in the TMR group was higher than the control group after 6 months (RR = 1.19, 95% CI: 1.07-1.31).

Conclusion: MI and TMR effectively improved treatment adherence, particularly complete adherence. Therefore, this study suggests the potential of these two methods in enhancing adherence among MMT patients in Vietnam.

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短信提醒和动机访谈对越南美沙酮治疗依从性的有效性:一项随机对照试验。
背景:美沙酮维持治疗(MMT)是治疗阿片类药物依赖的有效方法。然而,不遵医嘱会增加戒断综合征、复发和用药过量的风险。方法:在越南胡志明市的三家诊所对450名阿片类药物依赖患者进行MMT的社区随机对照试验。患者随机分为对照组、短信提醒组和动机访谈组。每3个月评估一次治疗依从性,包括完全依从性、连续依从性和周末依从性。结果:6个月后,心肌梗死组的完全依从性明显高于对照组(RR = 1.36, 95% CI: 1.09-1.69)。与对照组相比,TMR组在3个月(RR = 1.27, 95% CI: 1.02-1.58)和6个月(RR = 1.28, 95% CI: 1.06-1.56)时的完全依从性更高。6个月后,TMR组的周末依从性高于对照组(RR = 1.19, 95% CI: 1.07-1.31)。结论:心肌梗死和TMR有效提高了治疗依从性,尤其是完全依从性。因此,本研究提示这两种方法在提高越南MMT患者依从性方面的潜力。
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