Investigating the Multigenerational Effects of DDT Residues Exposure on Dental Development in Wistar Rats.

Environmental toxicology and pharmacology Pub Date : 2025-01-26 DOI:10.1016/j.etap.2025.104646

Camilla de Marchi Sanches Azevedo, Fernanda Coleraus, Ana Tereza Bittencourt Guimarães, C Christian Kirschneck, Erika Calvano Küchler

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Abstract

The pesticide Dichlorodiphenyltrichloroethane (DDT) and its degradation by-products (Dichlorodiphenyldichloroethane-DDD and dichlorodiphenyldichloroethylene-DDE) are health concerns. This study aimed to investigate the impact of multigenerational exposure to traces of DDD and DDE on odontogenesis Wistar rats were allocated in 4 groups over 2 generations (F1 and F2). Water was provided ad libitum throughout the animal's life groups: control - natural water; DDD - 0.0147µM DDD; DDE - 0.0056µM DDE; and DDD+DDE - mixture of the two solutions. They were euthanized and the heads removed for computer tomography for molars measurements (mesio-distal - MD and buccal-lingual BL dimensions). DDE increased the first molar dimensions (p<0.05) and maxillary third molars (p<0.05). DDD resulted in mandible third molar reduction (p<0.05). There was no difference between F1 and F2 and between sexes (p>0.05). In conclusion, DDE was associated with a possible hypertrophic effect on maxillary molars developmental, while DDD was associated to reduction in mandible molars.

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Environmental toxicology and pharmacology

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