Investigating the multigenerational effects of DDT residues exposure on dental development in Wistar rats

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES Environmental toxicology and pharmacology Pub Date : 2025-03-01 Epub Date: 2025-01-26 DOI:10.1016/j.etap.2025.104646

Camilla de Marchi Sanches Azevedo , Fernanda Coleraus , Ana Tereza Bittencourt Guimarães , Christian Kirschneck , Erika Calvano Küchler

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Abstract

The pesticide Dichlorodiphenyltrichloroethane (DDT) and its degradation by-products (Dichlorodiphenyldichloroethane-DDD and dichlorodiphenyldichloroethylene-DDE) are health concerns. This study aimed to investigate the impact of multigenerational exposure to traces of DDD and DDE on odontogenesis Wistar rats were allocated in 4 groups over 2 generations (F1 and F2). Water was provided ad libitum throughout the animal's life groups: control - natural water; DDD - 0.0147 µM DDD; DDE - 0.0056 µM DDE; and DDD+DDE - mixture of the two solutions. They were euthanized and the heads removed for computer tomography for molars measurements (mesio-distal – MD and buccal-lingual BL dimensions). DDE increased the first molar dimensions (p < 0.05) and maxillary third molars (p < 0.05). DDD resulted in mandible third molar reduction (p < 0.05). There was no difference between F1 and F2 and between sexes (p > 0.05). In conclusion, DDE was associated with a possible hypertrophic effect on maxillary molars developmental, while DDD was associated to reduction in mandible molars.

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研究滴滴涕残留暴露对Wistar大鼠牙齿发育的多代影响。

农药二氯二苯三氯乙烷（滴滴涕）及其降解副产物（二氯二苯二氯乙烷- ddd和二氯二苯二氯乙烷- dde）是令人关切的健康问题。本研究旨在探讨多代暴露于微量DDD和DDE对牙发育的影响。Wistar大鼠分为4组，共2代（F1和F2）。在动物的整个生命组中，水是随意提供的：对照组-天然水；DDD - 0.0147µm DDD；Dde - 0.0056微米Dde；DDD+DDE -两种溶液的混合物。他们被安乐死，头部被移除进行计算机断层扫描，以测量臼齿（中-远端- MD和颊-舌BL尺寸）。DDE增加了第一磨牙尺寸（p0.05）。综上所述，DDE可能与上颌磨牙发育肥厚有关，而DDD可能与下颌骨磨牙发育减少有关。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.