Yongchun Zhu, Xianyan Zhang, Chuanteng Ma, Xingtao Ren, Wenxue Wang, Kaijin Zhang, Guojian Zhang, Qian Che, Tianjiao Zhu, Dehai Li
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引用次数: 0
Abstract
Malfilamentosides are a class of fungal secondary metabolites characterized by glycosylated furanone scaffold; however, the enzyme that catalyzes the O-glycosylation of the furanone core with N-acetylglucosamine (GlcNAc) has not yet been identified. In this study, we discovered and identified the biosynthetic gene cluster of the malfilamentosides. In vivo and in vitro investigations revealed that a glycosyltransferase, MftB, catalyzes the O-glycosylation of the furanone scaffold with GlcNAc. Furthermore, MftB exhibits broad promiscuity toward glycosyl donors and acceptors, highlighting its potential in glycoside production.
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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