Effects of stevia consumption on appetite in adults: A systematic review and dose–response meta-analysis of randomized controlled trials

IF 7.4 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Reviews Pub Date : 2025-01-30 DOI:10.1111/obr.13902

Marzieh Zare, Mobina Zeinalabedini, Soraiya Ebrahimpour-Koujan, Leila Azadbakht

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Abstract

Stevia is an intense, calorie-free sweetener that is frequently used to reduce energy intake; however, studies examining its effects on appetite and energy intake have produced mixed results, indicating that a definitive consensus has not yet been reached. This systematic review and meta-analysis aimed to determine the impact of stevia on appetite and energy intake in adults. The PROSPERO registration number for this research is CRD42023414411. The databases PubMed (MEDLINE), Scopus, Web of Science, and Google Scholar were systematically searched. In addition, the reference lists of extracted articles and pertinent reviews were examined. Two evaluators performed screening, quality assessment, and data extraction independently. Furthermore, the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach was employed to systematically assess the certainty level of the evidence presented in our study. Eleven clinical trials with a total of 428 participants were included. We found no significant changes in any appetite scores following stevia consumption (very low to moderate certainty of the evidence). Moreover, subgroup analyses demonstrated the scores of desires to eat increased significantly in the oral intake of stevia and not enteral intake subgroup (WMD: 0.45; 95% CI: 0.009, 0.89; P = 0.046). In addition, the number of studies reporting energy intake was limited, preventing a meta-analysis of this variable. In conclusion, stevia consumption has no significant effect on appetite scores in adults but it seems that more long-term clinical trials are needed to obtain more accurate results.

Practitioner Point

Stevia, as a non-nutritive sweetener, has no significant effect on appetite scores in adults.

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甜菊糖对成人食欲的影响：随机对照试验的系统回顾和剂量反应荟萃分析。

甜菊糖是一种高强度、无热量的甜味剂，经常用于减少能量摄入；然而，关于其对食欲和能量摄入影响的研究产生了不同的结果，表明尚未达成明确的共识。本系统综述和荟萃分析旨在确定甜菊糖对成人食欲和能量摄入的影响。本研究的PROSPERO注册号为CRD42023414411。系统检索PubMed （MEDLINE）、Scopus、Web of Science、b谷歌Scholar等数据库。此外，还检查了摘录文章的参考文献列表和相关综述。两名评估人员独立进行筛选、质量评估和数据提取。此外，GRADE（建议、评估、发展和评价的分级）方法被用于系统地评估我们研究中提出的证据的确定性水平。11项临床试验共纳入428名受试者。我们发现食用甜菊糖后食欲评分没有显著变化（证据的确定性非常低到中等）。此外，亚组分析表明，在口服摄入甜菊糖的亚组中，渴望进食的得分显著增加，而在肠内摄入亚组中则没有(WMD: 0.45；95% ci: 0.009, 0.89；p = 0.046)。此外，报告能量摄入的研究数量有限，因此无法对该变量进行荟萃分析。总之，食用甜菊糖对成年人的食欲评分没有显著影响，但似乎需要更长期的临床试验来获得更准确的结果。医生观点：甜菊糖作为一种非营养性甜味剂，对成年人的食欲评分没有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Reviews 医学-内分泌学与代谢

CiteScore

19.30

自引率

1.10%

发文量

130

审稿时长

1 months

期刊介绍： Obesity Reviews is a monthly journal publishing reviews on all disciplines related to obesity and its comorbidities. This includes basic and behavioral sciences, clinical treatment and outcomes, epidemiology, prevention and public health. The journal should, therefore, appeal to all professionals with an interest in obesity and its comorbidities. Review types may include systematic narrative reviews, quantitative meta-analyses and narrative reviews but all must offer new insights, critical or novel perspectives that will enhance the state of knowledge in the field. The editorial policy is to publish high quality peer-reviewed manuscripts that provide needed new insight into all aspects of obesity and its related comorbidities while minimizing the period between submission and publication.