MR Imaging Techniques for Microenvironment Mapping of the Glioma Tumors: A Systematic Review

IF 3.9 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Academic Radiology Pub Date : 2025-07-01 Epub Date: 2025-02-01 DOI:10.1016/j.acra.2025.01.024

Fateme Shahedi , Shahrokh Naseri , Mahdi Momennezhad , Hoda Zare

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Abstract

Rationale and Objectives

The tumor microenvironment (TME) is a critical regulator of cancer progression, metastasis, and treatment response. Currently, various imaging approaches exist to assess the pathophysiological features of the TME. This systematic review provides an overview of magnetic resonance imaging (MRI) methods used in clinical practice to characterize the pathophysiological features of the gliomas TME.

Methods

This review involved a systematic comprehensive search of original open-access articles reporting the clinical use of MR imaging in glioma patients of all ages in the PubMed, Scopus, and Web of Science databases between January 2010 and December 2023. We restricted our research to papers published in the English language.

Results

A total of 1137 studies were preliminarily identified through electronic database searches. After duplicate studies were removed, 44 studies met the eligibility criteria. The glioma TME was accompanied by alterations in metabolism, pH, vascularity, oxygenation, and extracellular matrix components, including tumor-associated macrophages, and sodium concentration.

Conclusion

Multiparametric MRI is capable of noninvasively assessing the pathophysiological features and tumor-supportive niches of the TME, which is in line with its application in personalized medicine.

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神经胶质瘤肿瘤微环境定位的MR成像技术：系统综述。

基本原理和目的：肿瘤微环境（tumor microenvironment， TME）是癌症进展、转移和治疗反应的关键调节因子。目前，有多种影像学方法来评估TME的病理生理特征。本系统综述了磁共振成像（MRI）方法在临床实践中用于表征胶质瘤TME的病理生理特征。方法：本综述系统地检索了PubMed、Scopus和Web of Science数据库中2010年1月至2023年12月期间所有年龄段胶质瘤患者MR成像临床应用的原始开放获取文章。我们的研究仅限于用英语发表的论文。结果：通过电子数据库检索，初步筛选出1137篇研究。删除重复研究后，有44项研究符合入选标准。胶质瘤TME伴有代谢、pH、血管、氧合和细胞外基质成分（包括肿瘤相关巨噬细胞）和钠浓度的改变。结论：多参数MRI能够无创评估TME的病理生理特征和肿瘤支持龛，符合其在个体化医疗中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Academic Radiology 医学-核医学

CiteScore

7.60

自引率

10.40%

发文量

432

审稿时长

18 days

期刊介绍： Academic Radiology publishes original reports of clinical and laboratory investigations in diagnostic imaging, the diagnostic use of radioactive isotopes, computed tomography, positron emission tomography, magnetic resonance imaging, ultrasound, digital subtraction angiography, image-guided interventions and related techniques. It also includes brief technical reports describing original observations, techniques, and instrumental developments; state-of-the-art reports on clinical issues, new technology and other topics of current medical importance; meta-analyses; scientific studies and opinions on radiologic education; and letters to the Editor.