The novel Bacillus thuringiensis HSY204 as a potential bioinsecticide with efficacy against Aedes aegypti larvae

IF 4 1区农林科学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Pesticide Biochemistry and Physiology Pub Date : 2025-03-01 Epub Date: 2025-01-23 DOI:10.1016/j.pestbp.2025.106309

Qi Lin , Jiangyu Wu , Xiao Feng , Pan Yang , Coline C. Jaworski , Shakil Ahmad , Wenfei Zhang

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Abstract

Bacillus thuringiensis (Bt), renowned for its potential, rapid action and environmental sustainability, remains an understudied group, particularly in newly identified strains. In this study, we screened a novel Bt strain, HSY204, extracted from soil samples. Our results revealed that HSY204 belonged to a new species of Bt with remarkable efficacy against Aedes aegypti larvae. The complete HSY204 genome analysis revealed nine toxin genes. In particular, a protein similar to Xpp37Aa showed very promising effectiveness in mosquito suppression, though surpassed by Bacillus thuringiensis subsp. israelensis (Bti). This research provides a valuable background for future biotechnological applications of HSY204 strain as a basis for the production of commercial bioinsecticides, thereby contributing to the development of innovative and environmentally friendly bioinsecticide strategies.

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苏云金芽孢杆菌HSY204对埃及伊蚊幼虫具有良好的生物杀灭效果

苏云金芽孢杆菌（Bacillus thuringiensis, Bt）以其潜力、快速行动和环境可持续性而闻名，但仍是一个研究不足的群体，特别是在新发现的菌株中。在本研究中，我们从土壤样品中筛选了一株新的Bt菌株HSY204。结果表明，HSY204属一种对埃及伊蚊幼虫有显著杀伤效果的Bt新菌株。HSY204全基因组分析显示了9个毒素基因。其中，一种与Xpp37Aa相似的蛋白在抑制蚊子方面表现出了非常有希望的效果，尽管它被苏云金芽孢杆菌亚种所超越。israelensis发言)。本研究为HSY204菌株未来的生物技术应用提供了有价值的背景，为商业化生物杀虫剂的生产提供了基础，从而有助于开发创新和环保的生物杀虫剂策略。

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来源期刊

Pesticide Biochemistry and Physiology 生物-昆虫学

CiteScore

7.00

自引率

8.50%

发文量

238

审稿时长

4.2 months

期刊介绍： Pesticide Biochemistry and Physiology publishes original scientific articles pertaining to the mode of action of plant protection agents such as insecticides, fungicides, herbicides, and similar compounds, including nonlethal pest control agents, biosynthesis of pheromones, hormones, and plant resistance agents. Manuscripts may include a biochemical, physiological, or molecular study for an understanding of comparative toxicology or selective toxicity of both target and nontarget organisms. Particular interest will be given to studies on the molecular biology of pest control, toxicology, and pesticide resistance. Research Areas Emphasized Include the Biochemistry and Physiology of: • Comparative toxicity • Mode of action • Pathophysiology • Plant growth regulators • Resistance • Other effects of pesticides on both parasites and hosts.