Yuya Yokoyama, Dr. Shinya Ariyasu, Dr. Masayuki Karasawa, Chie Kasai, Dr. Yuichiro Aiba, Dr. Hiroshi Sugimoto, Prof. Dr. Osami Shoji
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引用次数: 0
Abstract
The Front Cover shows the synergistic effects of a decoy molecule and directed evolution in cytochrome P450BM3. The developed P450BM3 mutant exhibits significantly high catalytic activity toward the hydroxylation of benzene, toluene, and propane in the presence of a natural decoy molecule, N-decanoyl homoserine lactone. This research demonstrates that exploring the vast combinations of mutations and decoy molecules—like a “space probe”—can lead to exceptional functional outcomes. More information can be found in the Research Article by S. Ariyasu, H. Sugimoto, O. Shoji and co-workers (DOI: 10.1002/cctc.202401641).
封面显示了细胞色素P450BM3诱骗分子和定向进化的协同效应。该P450BM3突变体在天然诱骗分子n -癸醇高丝氨酸内酯的存在下，对苯、甲苯和丙烷的羟基化表现出显著的高催化活性。这项研究表明，探索突变和诱饵分子的巨大组合——就像一个“太空探测器”——可以导致特殊的功能结果。更多信息可以在S. Ariyasu， H. Sugimoto， O. Shoji及其同事的研究文章中找到（DOI: 10.1002/cctc.202401641）。
期刊介绍：
With an impact factor of 4.495 (2018), ChemCatChem is one of the premier journals in the field of catalysis. The journal provides primary research papers and critical secondary information on heterogeneous, homogeneous and bio- and nanocatalysis. The journal is well placed to strengthen cross-communication within between these communities. Its authors and readers come from academia, the chemical industry, and government laboratories across the world. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and is supported by the German Catalysis Society.
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