Efficient, One-Pot, Green Syntheses of Analogues of 3,4-Dihydro-2H Pyrroles as Potential New Antifungal and Antibacterial Agents.

Abstract

An efficient method offering high convenience and sustainability, showcasing the potential for the green synthesis strategies has been developed. The protocol presents a straightforward, environmentally friendly approach for construction of substituted 3,4-dihydro-2H pyrroles in an aqueous ethanol that describes a one-pot multistep reaction sequence, initiated with a Claisen–Schmidt Condensation, followed by the Michael addition of nitro methane to chalcone, next to line being reduction an intramolecular cyclization steps to yield the desired product in moderate to higher yields. Underscoring the effectiveness of the sequence, the biological activities has also been evaluated for the compounds. Preliminary studies indicating promising antibacterial and antifungal properties, make these compounds significant for further pharmaceutical development. The use of ethanol as a green solvent in the one-pot pyrroline synthesis process underscores the importance of environmentally friendly solvents, significantly reducing the environmental impact and aligning with the principles of sustainable chemistry. The green synthetic strategy combined with the notable biological activities demonstrates the dual benefit of this research, contributing both to the field of green chemistry and to the therapeutic drug discovery.